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Biodegradable Magnesium-Based Implants in Orthopedics-A General Review and Perspectives.
Advanced Science ( IF 15.1 ) Pub Date : 2020-02-28 , DOI: 10.1002/advs.201902443
Jia-Li Wang 1, 2 , Jian-Kun Xu 2, 3 , Chelsea Hopkins 2 , Dick Ho-Kiu Chow 2, 3 , Ling Qin 2, 3
Affiliation  

Biodegradable Mg-based metals may be promising orthopedic implants for treating challenging bone diseases, attributed to their desirable mechanical and osteopromotive properties. This Review summarizes the current status and future research trends for Mg-based orthopedic implants. First, the properties between Mg-based implants and traditional orthopedic implants are compared on the following aspects: in vitro and in vivo degradation mechanisms of Mg-based implants, peri-implant bone responses, the fate of the degradation products, and the cellular and molecular mechanisms underlying the beneficial effects of Mg ions on osteogenesis. Then, the preclinical studies conducted at the low weight bearing sites of animals are introduced. The innovative strategies (for example, via designing Mg-containing hybrid systems) are discussed to address the limitations of Mg-based metals prior to their clinical applications at weight-bearing sites. Finally, the available clinical studies are summarized and the challenges and perspectives of Mg-based orthopedic implants are discussed. Taken together, the progress made on the development of Mg-based implants in basic, translational, and clinical research has laid down a foundation for developing a new era in the treatment of challenging and prevalent bone diseases.

中文翻译:

骨科中可生物降解的镁基植入物——总体回顾和展望。

可生物降解的镁基金属由于其理想的机械和骨促进特性,可能成为治疗具有挑战性的骨疾病的有前景的骨科植入物。本综述总结了镁基骨科植入物的现状和未来研究趋势。首先,从镁基植入物的体外和体内降解机制、种植体周围的骨反应、降解产物的去向以及细胞和体内的降解机制等方面比较了镁基植入物与传统骨科植入物的性能。镁离子对成骨有益作用的分子机制。然后介绍了在动物低负重部位进行的临床前研究。讨论了创新策略(例如,通过设计含镁混合系统),以解决镁基金属在负重部位的临床应用之前的局限性。最后,总结了现有的临床研究,并讨论了镁基骨科植入物的挑战和前景。总而言之,镁基种植体在基础、转化和临床研究方面取得的进展为开辟治疗具有挑战性和普遍性的骨疾病的新时代奠定了基础。
更新日期:2020-04-21
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