A practical protocol for the synthesis of 4‐sulfonyl pyrazoles via the reactions of readily available N,N‐dimethyl enaminones and sulfonyl hydrazines has been developed via the catalysis of molecular iodine in the presence of TBHP and NaHCO₃ at room temperature. The pyrazole products have been constructed via the tandem C(sp²)−H sulfonylation and a pyrazole annulation without employing any transition metal catalyst or reagent, thus providing a practical new method for the synthesis of the novel pyrazoles bearing a sulfonyl side chain in the heterocycle.

中文翻译：

---

不含过渡金属的CH磺酰化反应和吡唑环流级联反应，可合成4-磺酰基吡唑

在室温下，在TBHP和NaHCO ₃存在下，通过分子碘的催化作用，已经开发出了一种通过容易获得的N，N-二甲基烯胺酮与磺酰基肼合成4-磺酰基吡唑的实用方案。吡唑产品是通过串联C（sp ²）-H磺酰化反应和吡唑环合反应制得的，无需使用任何过渡金属催化剂或试剂，从而为合成新型的带有磺酰基侧链的吡唑提供了一种实用的新方法。杂环。