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Rapid viral rebound after analytical treatment interruption in patients with very small HIV reservoir and minimal on-going viral transcription
Journal of the International AIDS Society ( IF 6 ) Pub Date : 2020-02-01 , DOI: 10.1002/jia2.25453 Pieter Pannus 1, 2 , Sofie Rutsaert 3 , Stéphane De Wit 4 , Sabine D Allard 5 , Guido Vanham 1, 2 , Basiel Cole 3 , Coca Nescoi 4 , Joeri Aerts 6 , Ward De Spiegelaere 7 , Achilleas Tsoumanis 1 , Marie-Madeleine Couttenye 8 , Natacha Herssens 1 , Marie-Angélique De Scheerder 3 , Linos Vandekerckhove 3 , Eric Florence 1
Journal of the International AIDS Society ( IF 6 ) Pub Date : 2020-02-01 , DOI: 10.1002/jia2.25453 Pieter Pannus 1, 2 , Sofie Rutsaert 3 , Stéphane De Wit 4 , Sabine D Allard 5 , Guido Vanham 1, 2 , Basiel Cole 3 , Coca Nescoi 4 , Joeri Aerts 6 , Ward De Spiegelaere 7 , Achilleas Tsoumanis 1 , Marie-Madeleine Couttenye 8 , Natacha Herssens 1 , Marie-Angélique De Scheerder 3 , Linos Vandekerckhove 3 , Eric Florence 1
Affiliation
Viral remission after analytical treatment interruption (ATI), termed post‐treatment control, has been described in a small proportion of HIV‐positive patients. This phenomenon has been separately associated to both low levels of HIV‐1 proviral DNA as well as cell‐associated RNA. We investigated whether the combination of both parameters could help predict delayed viral rebound after treatment interruption (TI).
中文翻译：
HIV 储存库非常小且持续病毒转录最少的患者在分析治疗中断后病毒迅速反弹
分析性治疗中断 (ATI) 后病毒缓解，称为治疗后控制，已在一小部分 HIV 阳性患者中得到描述。这种现象分别与低水平的 HIV-1 前病毒 DNA 和细胞相关 RNA 相关。我们调查了这两个参数的组合是否有助于预测治疗中断 (TI) 后延迟的病毒反弹。
更新日期：2020-02-01
中文翻译：
HIV 储存库非常小且持续病毒转录最少的患者在分析治疗中断后病毒迅速反弹
分析性治疗中断 (ATI) 后病毒缓解，称为治疗后控制，已在一小部分 HIV 阳性患者中得到描述。这种现象分别与低水平的 HIV-1 前病毒 DNA 和细胞相关 RNA 相关。我们调查了这两个参数的组合是否有助于预测治疗中断 (TI) 后延迟的病毒反弹。
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