L-Cysteine decorated nanoscale metal–organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy,Chemical Communications

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L-Cysteine decorated nanoscale metal–organic frameworks delivering valproic acid/cisplatin for drug-resistant lung cancer therapy
Chemical Communications ( IF 4.9 ) Pub Date : 2020/02/28 , DOI: 10.1039/c9cc09712k
Wenna Guo _{1,

2,

3,

4,

5} , Zengzhen Chen _{1,

2,

3,

4,

5} , Longfei Tan _{1,

2,

3,

4,

5} , Qiong Wu _{1,

2,

3,

4,

5} , Xiangling Ren _{1,

2,

3,

4,

5} , Changhui Fu _{1,

2,

3,

4,

5} , Yongxing Du _{6,

7,

8,

9} , Jun Ren _{1,

2,

3,

4,

5} , Xianwei Meng _{1,

2,

3,

4,

5}

Affiliation

We design multifunctional CDDP-VPA@ZrMOF-Cys-PEG nanoparticles (CVZP NPs) based on the properties of valproic acid (VPA) that can downregulate the expression of vascular endothelial growth factor (VEGF) to reduce the drug resistance of tumor cells. In vivo experiments confirm that chemotherapy combined with microwave thermal therapy (MWTT) can significantly improve the therapeutic effect of cisplatin-resistant lung cancer.

中文翻译：

L-半胱氨酸修饰的纳米金属-有机骨架可提供丙戊酸/顺铂用于耐药性肺癌治疗

我们基于丙戊酸（VPA）的特性设计多功能CDDP-VPA @ ZrMOF-Cys-PEG纳米颗粒（CVZP NPs），它可以下调血管内皮生长因子（VEGF）的表达，从而降低肿瘤细胞的耐药性。体内实验证实化学疗法与微波热疗法（MWTT）结合可以显着提高对顺铂耐药的肺癌的治疗效果。

更新日期：2020-04-03

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