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Strategies for engineering advanced nanomedicines for gas therapy of cancer
National Science Review ( IF 20.6 ) Pub Date : 2020-02-27 , DOI: 10.1093/nsr/nwaa034
Yingshuai Wang 1 , Tian Yang 1 , Qianjun He 1
Affiliation  

As an emerging and promising treatment method, gas therapy has attracted more and more attention for treatment of inflammation-related diseases, especially cancer. However, therapeutic/therapy-assisted gases (NO, CO, H2S, H2, O2, SO2 and CO2) and most of their prodrugs lack the abilities of active intratumoral accumulation and controlled gas release, resulting in limited cancer therapy efficacy and potential side effects. Therefore, development of nanomedicines to realize tumor-targeted and controlled release of therapeutic/therapy-assisted gases is greatly desired, and also the combination of other therapeutic modes with gas therapy by multifunctional nanocarrier platforms can augment cancer therapy efficacy and also reduce their side effects. The design of nanomedicines with these functions is vitally important, but challenging. In this review, we summarize a series of engineering strategies for construction of advanced gas-releasing nanomedicines from four aspects: (1) stimuli-responsive strategies for controlled gas release; (2) catalytic strategies for controlled gas release; (3) tumor-targeted gas delivery strategies; (4) multi-model combination strategies based on gas therapy. Moreover, we highlight current issues and gaps in knowledge, and envisage current trends and future prospects of advanced nanomedicines for gas therapy of cancer. This review aims to inspire and guide the engineering of advanced gas-releasing nanomedicines.

中文翻译:

用于癌症气体治疗的先进纳米药物工程设计策略

气体疗法作为一种新兴的、有前景的治疗方法,在炎症相关疾病,尤其是癌症的治疗中越来越受到重视。然而,治疗/治疗辅助气体(NO、CO、H 2 S、H 2、O 2、SO 2和 CO 2) 并且他们的大多数前药缺乏主动肿瘤内积聚和控制气体释放的能力,导致癌症治疗效果有限和潜在的副作用。因此,非常需要开发纳米药物以实现治疗/治疗辅助气体的肿瘤靶向和控释,并且通过多功能纳米载体平台将其他治疗模式与气体治疗相结合可以提高癌症治疗效果并减少其副作用. 具有这些功能的纳米药物的设计至关重要,但具有挑战性。在这篇综述中,我们从四个方面总结了一系列构建先进气体释放纳米药物的工程策略:(1)控制气体释放的刺激响应策略;(2) 控制气体释放的催化策略;(3) 肿瘤靶向气体输送策略;(4)基于气体疗法的多模式联合策略。此外,我们强调了当前的问题和知识差距,并展望了用于癌症气体治疗的先进纳米药物的当前趋势和未来前景。本综述旨在启发和指导先进的气体释放纳米药物的工程设计。
更新日期:2020-02-27
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