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Neonatal oxygen saturations and blood pressure at school-age in children born extremely preterm: a cohort study.
Journal of Perinatology ( IF 2.9 ) Pub Date : 2020-02-28 , DOI: 10.1038/s41372-020-0619-z
Marina S Oren 1 , Vlad Ianus 1 , Betty R Vohr 2 , Susan R Hintz 3 , Barbara T Do 4 , Abhik Das 5 , Seetha Shankaran 6 , Rosemary D Higgins 7 , Kristi L Watterberg 1 ,
Affiliation  

OBJECTIVE To explore the relationship between neonatal oxygen saturation and BP at age 6-7 years in a cohort of infants born extremely preterm. STUDY DESIGN Infants <28 weeks gestation were assigned to a higher or lower oxygen saturation target. Oximeter data were monitored throughout the neonatal period. A subset of survivors was seen at age 6. BP was measured and compared by group assignment, achieved saturations, and time spent in hypoxemia (saturations <80%). RESULTS There was no difference in systolic or diastolic BP between assigned groups. Median achieved weekly oxygen saturation was not associated with BP. Longer duration of hypoxemia during the first week of age was associated with higher systolic BP. CONCLUSIONS Neither target nor actual median oxygen saturations in this study was associated with BP at school age. Increased duration of hypoxemia in the first postnatal week was associated with higher systolic BP at 6-7 years of age.

中文翻译:

极早产儿学龄时的新生儿氧饱和度和血压:一项队列研究。

目的 探讨极早产儿队列中新生儿氧饱和度与 6-7 岁时血压之间的关系。研究设计 妊娠<28周的婴儿被分配至较高或较低的氧饱和度目标。在整个新生儿期监测血氧计数据。一部分幸存者在 6 岁时就诊。通过分组测量和比较血压、达到的饱和度以及低氧血症所花费的时间(饱和度 <80%)。结果 分配组之间的收缩压或舒张压没有差异。每周达到的中位氧饱和度与血压无关。第一周内低氧血症持续时间较长与较高的收缩压相关。结论 本研究中的目标氧饱和度和实际中位氧饱和度均与学龄血压无关。产后第一周低氧血症持续时间延长与 6-7 岁时收缩压升高相关。
更新日期:2020-02-28
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