当前位置: X-MOL 学术Sleep Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Comparative study of the substantia nigra echogenicity and 123I-Ioflupane SPECT in patients with synucleinopathies with and without REM sleep behavior disorder.
Sleep Medicine ( IF 4.8 ) Pub Date : 2020-02-28 , DOI: 10.1016/j.sleep.2020.02.012
J Mašková 1 , D Školoudík 2 , P Štofaniková 1 , V Ibarburu 1 , D Kemlink 1 , D Zogala 3 , J Trnka 3 , R Krupička 4 , K Šonka 1 , E Růžička 1 , P Dušek 5
Affiliation  

OBJECTIVES Hyperechogenicity of the substantia nigra (SN) and abnormal dopamine transporter-single-photon emission computed tomography (DAT-SPECT) are biomarkers commonly used in the assessment of prodromal synucleinopathy. Our goals were as follows: (1) to compare echogenicity of SN in idiopathic rapid eye movement (REM) behavior disorder (iRBD), Parkinson's disease (PD) without RBD (PD-noRBD), PD with RBD (PD + RBD), and control subjects; and (2) to examine association between SN degeneration assessed by DAT-SPECT and SN echogenicity. PATIENTS/METHODS A total of 61 subjects with confirmed iRBD were examined using Movement Disorders Society-unified PD rating scale (MDS-UPDRS), TCS (transcranial sonography) and DAT-SPECT. The results were compared with 44 patients with PD (25% PD + RBD) and with 120 age-matched healthy subjects. RESULTS AND CONCLUSION The abnormal SN area was found in 75.5% PD, 23% iRBD and 7.3% controls. Median SN echogenicity area in PD (0.27 ± 0.22 cm2) was higher compared to iRBD (0.07 ± 0.07 cm2; p < 0.0001) and controls (0.05 ± 0.03 cm2; p < 0.0001). SN echogenicity in PD + RBD was not significantly different from PD-noRBD (0.30 vs. 0.22, p = 0.15). Abnormal DAT-SPECT was found in 16 iRBD (25.4%) and 44 PD subjects (100%). No correlation between the larger SN area and corresponding putaminal binding index was found in iRBD (r = -0.13, p = 0.29), nor in PD (r = -0.19, p = 0.22). The results of our study showed that: (1) SN echogenicity area in iRBD was higher compared to controls, but the hyperechogenicity was present only in a minority of iRBD patients; (2) SN echogenicity and DAT-SPECT binding index did not correlate in either group; and (3) SN echogenicity does not differ between PD with/without RBD.

中文翻译:

患有和没有REM睡眠行为障碍的突触核病患者黑质回声和123I-Ioflupane SPECT的比较研究。

目的黑质(SN)的超强回生性和多巴胺转运蛋白-单光子发射计算机断层扫描(DAT-SPECT)异常是通常用于评估前驱突触核病的生物标志物。我们的目标如下:(1)比较SN在特发性快速眼动(REM)行为障碍(iRBD),无RBD的帕金森病(PD)(PD-noRBD),有RBD的PD(PD + RBD)的回声性,和控制对象;(2)检查通过DAT-SPECT评估的SN变性与SN回声性之间的关联。患者/方法使用运动障碍学会统一的PD评分量表(MDS-UPDRS),TCS(经颅超声检查)和DAT-SPECT对总共61例确诊为iRBD的受试者进行了检查。将结果与44例PD患者(25%PD + RBD)和120位年龄相匹配的健康受试者进行了比较。结果与结论在75.5%的PD,23%的iRBD和7.3%的对照组中发现了异常的SN区域。与iRBD(0.07±0.07 cm2; p <0.0001)和对照(0.05±0.03 cm2; p <0.0001)相比,PD中的SN回声中性面积(0.27±0.22 cm2)更高。PD + RBD中的SN回声性与PD-noRBD无显着差异(0.30对0.22,p = 0.15)。在16名iRBD(25.4%)和44名PD受试者(100%)中发现了异常的DAT-SPECT。在iRBD(r = -0.13,p = 0.29)和PD(r = -0.19,p = 0.22)中,未发现较大的SN面积与相应的肠壁结合指数之间存在相关性。我们的研究结果表明:(1)iRBD的SN回声区域比对照组高,但仅少数的iRBD患者存在超回声;(2)两组的SN回声性和DAT-SPECT结合指数均不相关。
更新日期:2020-02-28
down
wechat
bug