Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control gene expression. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in mammalian cells. m6A modification is important for controlling many cellular and biological processes. Deregulation of m6A modification has been recently implicated in human carcinogenesis, including liver cancer. In this review, we summarize the recent findings on m6A regulation and its biological impacts in normal and cancer cells. We will focus on the deregulation of m6A modification and m6A regulators in liver diseases and liver cancers. We will highlight the clinical relevance of m6A deregulation in liver cancer. We will also discuss the potential of exploiting m6A modification for cancer diagnosis and therapeutics.

中文翻译：

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N6-甲基腺苷 (m6A) 失调在肝癌发生中的新兴作用。

肝癌是世界范围内常见的癌症。尽管肝癌发生的病因已明确，但其潜在的分子机制在很大程度上仍然难以捉摸。表观遗传失调，例如异常的 DNA 甲基化和组蛋白修饰，在肝癌发生中起关键作用。类似于 DNA 和核心组蛋白，mRNA 上的可逆化学修饰最近被认为是控制基因表达的重要调控机制。N6-甲基腺苷 (m6A) 是哺乳动物细胞中最普遍的内部 mRNA 修饰。m6A 修饰对于控制许多细胞和生物过程很重要。m6A 修饰的失调最近与人类致癌作用有关，包括肝癌。在这次审查中，我们总结了最近关于 m6A 调节及其对正常细胞和癌细胞的生物学影响的发现。我们将重点关注肝病和肝癌中 m6A 修饰和 m6A 调节剂的放松管制。我们将强调 m6A 失调在肝癌中的临床相关性。我们还将讨论利用 m6A 修饰进行癌症诊断和治疗的潜力。