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Comparison of frequency-domain and continuous-wave near-infrared spectroscopy devices during the immediate transition.
BMC Pediatrics ( IF 2.4 ) Pub Date : 2020-02-28 , DOI: 10.1186/s12887-020-1987-4
Tanja van Essen 1 , Tom G Goos 1, 2 , Liza van Ballegooijen 1 , Gerhard Pichler 3, 4 , Berndt Urlesberger 3, 4 , Irwin K M Reiss 1 , Rogier C J de Jonge 1, 5
Affiliation  

BACKGROUND Non-invasive monitoring of cerebral tissue oxygen saturation (rcSO2) during transition is of growing interest. Different near-infrared spectroscopy (NIRS) techniques have been developed to measure rcSO2. We compared rcSO2 values during the immediate transition in preterm neonates measured with frequency-domain NIRS (FD-NIRS) with those measured with continuous-wave NIRS (CW-NIRS) devices in prospective observational studies. METHODS We compared rcSO2 values measured with an FD-NIRS device during the first 15 min after birth in neonates with a gestational age ≥ 30 weeks but < 37 weeks born at the Erasmus MC- Sophia Children's Hospital, Rotterdam, the Netherlands, with similar values measured with a CW-NIRS device in neonates born at the Medical University of Graz, Austria. Mixed models were used to adjust for repeated rcSO2 measurements, with fixed effects for time (non-linear), device, respiratory support and the interaction of device and respiratory support with time. Additionally, parameters such as total haemoglobin concentration and oxygenated and deoxygenated haemoglobin concentrations measured by FD-NIRS were analysed. RESULTS Thirty-eight FD-NIRS measurements were compared with 58 CW-NIRS measurements. The FD-NIRS rcSO2 values were consistently higher than the CW-NIRS rcSO2 values in the first 12 min, irrespective of respiratory support. After adjustment for respiratory support, the time-dependent trend in rcSO2 differed significantly between techniques (p < 0.01). CONCLUSION As cerebral saturation measured with the FD-NIRS device differed significantly from that measured with the CW-NIRS device, differences in absolute values need to be interpreted with care. Although FD-NIRS devices have technical advantages over CW-NIRS devices, FD-NIRS devices may overestimate true cerebral oxygenation and their benefits might not outweigh the usability of the more clinically viable CW-NIRS devices.

中文翻译:

立即过渡期间频域和连续波近红外光谱仪的比较。

背景技术在过渡期间对脑组织氧饱和度(rcSO 2)的非侵入性监测越来越受到关注。已经开发了不同的近红外光谱(NIRS)技术来测量rcSO2。在前瞻性观察研究中,我们比较了频域近红外光谱仪(FD-NIRS)和连续波近红外光谱仪(CW-NIRS)所测量的早产儿在过渡期的rcSO2值。方法我们比较了在荷兰鹿特丹伊拉斯姆斯·索菲亚儿童医院出生,胎龄≥30周但≤37周的新生儿,在出生后前15分钟内使用FD-NIRS设备测量的rcSO2值,该值相似使用CW-NIRS装置对奥地利格拉茨医科大学出生的新生儿进行测量。混合模型用于调整重复的rcSO2测量,对时间(非线性),设备,呼吸支持以及设备和呼吸支持与时间的相互作用具有固定的影响。另外,分析了诸如总血红蛋白浓度以及通过FD-NIRS测量的氧化和脱氧血红蛋白浓度的参数。结果将38 FD-NIRS测量结果与58 CW-NIRS测量结果进行了比较。FD-NIRS rcSO2值在开始的12分钟内始终高于CW-NIRS rcSO2值,与呼吸支持无关。调整呼吸支持后,两种技术之间rcSO2的时间依赖性趋势存在显着差异(p <0.01)。结论由于FD-NIRS设备测量的大脑饱和度与CW-NIRS设备测量的大脑饱和度显着不同,绝对值的差异需要仔细解释。尽管FD-NIRS设备比CW-NIRS设备具有技术优势,但FD-NIRS设备可能会高估真实的大脑氧合,其益处可能不会超过临床上更可行的CW-NIRS设备的可用性。
更新日期:2020-02-28
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