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An experimental model for pressure drop evaluation in a stenosed coronary artery
Physics of Fluids ( IF 4.6 ) Pub Date : 2020-02-01 , DOI: 10.1063/1.5139701
Navid Freidoonimehr 1 , Rey Chin 1 , Anthony Zander 1 , Maziar Arjomandi 1
Affiliation  

Non-invasive measurement of pressure drop has great clinical significance for the treatment of coronary artery diseases. The objective of this study is to develop a relationship that can estimate pressure drop in a stenosed coronary artery model as a function of different parameters such as blood viscosity, artery length and diameter, flow rate and flow profile, and shape and degrees of stenosis. Experimental pressure measurements from a wide range of degrees of stenosis and critical simplified geometries of stenosis along with different unsteady flow profiles are employed to evaluate the pressure drop equation. To calculate the blockage term of the pressure drop, several experimental cases are investigated, and the results show that the blockage factor is strongly dependent on the shape and degree of stenosis. Furthermore, different unsteady flow profiles are applied to calculate the pulsatile pressure drop term, and it is found that the pulsatility parameter is not a function of the flow profile or the shape of the stenosis. However, it is only a function of the degree of stenosis. To test the validity of the developed equation, pressure drops through stenosed coronary artery models with the real physiological flow profile of the left and right coronary arteries were predicted and compared with the experimental measurements. The proposed equation is able to determine the pressure drop inside a stenosed coronary artery non-invasively using the measurement of the flow profile inside the artery as well as the images of the stenosed coronary artery obtained based on the non-invasive methods.

中文翻译:

用于评估狭窄冠状动脉压降的实验模型

压降的无创测量对于冠状动脉疾病的治疗具有重要的临床意义。本研究的目的是建立一种关系,该关系可以估计狭窄冠状动脉模型中的压降,作为不同参数的函数,例如血液粘度、动脉长度和直径、流速和流量分布以及狭窄的形状和程度。来自各种狭窄程度和狭窄的临界简化几何形状以及不同的不稳定流动剖面的实验压力测量被用来评估压降方程。为了计算压降的阻塞项,研究了几个实验案例,结果表明阻塞因子强烈依赖于狭窄的形状和程度。此外,应用不同的非稳态流动剖面来计算脉动压降项,发现脉动参数不是流动剖面或狭窄形状的函数。然而,它只是狭窄程度的函数。为了测试所开发方程的有效性,预测了冠状动脉狭窄模型的压降,并预测了左右冠状动脉的真实生理流量曲线,并与实验测量值进行了比较。所提出的方程能够使用动脉内流动剖面的测量以及基于非侵入性方法获得的狭窄冠状动脉的图像来非侵入性地确定狭窄冠状动脉内的压降。并且发现脉动参数不是流动剖面或狭窄形状的函数。然而,它只是狭窄程度的函数。为了测试所开发方程的有效性,预测了冠状动脉狭窄模型的压降,并预测了左右冠状动脉的真实生理流量曲线,并与实验测量值进行了比较。所提出的方程能够使用动脉内流动剖面的测量以及基于非侵入性方法获得的狭窄冠状动脉的图像来非侵入性地确定狭窄冠状动脉内的压降。并且发现脉动参数不是流动剖面或狭窄形状的函数。然而,它只是狭窄程度的函数。为了测试所开发方程的有效性,预测了冠状动脉狭窄模型的压降,并预测了左右冠状动脉的真实生理流量曲线,并与实验测量值进行了比较。所提出的方程能够使用动脉内流动剖面的测量以及基于非侵入性方法获得的狭窄冠状动脉的图像来非侵入性地确定狭窄冠状动脉内的压降。为了测试所开发方程的有效性,预测了冠状动脉狭窄模型的压降,并预测了左右冠状动脉的真实生理流量曲线,并与实验测量值进行了比较。所提出的方程能够使用动脉内流动剖面的测量以及基于非侵入性方法获得的狭窄冠状动脉的图像来非侵入性地确定狭窄冠状动脉内的压降。为了测试所开发方程的有效性,预测了冠状动脉狭窄模型的压降,并预测了左右冠状动脉的真实生理流量曲线,并与实验测量值进行了比较。所提出的方程能够使用动脉内流动剖面的测量以及基于非侵入性方法获得的狭窄冠状动脉的图像来非侵入性地确定狭窄冠状动脉内的压降。
更新日期:2020-02-01
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