The pre-mounted dry transcatheter aortic valve implantation (TAVI) valve is a new technology in the development of biological heart valves. Dry valves do not need to be placed in special preservation solution and can be opened and used immediately, meeting the needs of clinical emergency valve implantation. However, current biological valves obtained by simple air drying cannot be unfolded quickly. In addition, the crimping process leads to structural damage to the valve fiber microstructure, reducing the service life of biological valves. Furthermore, current biological valves still have problems such as calcification, endothelialization difficulty, and immune rejection. In this study, a poly(ethylene glycol)methacrylate (PEGMA) hydrogel hybrid pericardium loaded with REDV was developed. The PEGMA monomer solution can penetrate the space of the pericardium. REDV was loaded into the PEGMA hydrogel, which was hybridized with pericardium via in situ polymerization. The results showed improved unfolding properties, less mechanical damage after crimping, and improved endothelialization potential of the biological valve. Thus, REDV-loaded PEGMA hydrogel hybrid pericardium is a promising approach for obtaining pre-mounted dry TAVI valves with enhanced endothelialization properties.

中文翻译：

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预装载的干式TAVI瓣膜，使用加载了REDV的PEGMA水凝胶杂合心包膜，具有改善的内皮化潜力

预先安装的干式经导管主动脉瓣植入（TAVI）阀是生物心脏瓣膜开发中的一项新技术。干阀无需放置在特殊的保存溶液中，可以立即打开并使用，满足临床紧急瓣膜植入的需求。然而，当前通过简单的空气干燥获得的生物瓣膜不能迅速展开。另外，压接过程导致瓣膜纤维微结构的结构损坏，从而缩短了生物瓣膜的使用寿命。此外，当前的生物瓣膜仍具有诸如钙化，内皮化困难和免疫排斥的问题。在这项研究中，开发了载有REDV的聚（甲基丙烯酸乙二醇酯）（PEGMA）水凝胶杂化心包。PEGMA单体溶液可以穿透心包空间。将REDV装入PEGMA水凝胶，与心包膜杂交通过原位聚合。结果显示改善的展开特性，压接后机械损伤较小，并且改善了生物瓣膜的内皮化潜力。因此，加载REDV的PEGMA水凝胶混合心包膜是获得具有增强的内皮化特性的预安装干式TAVI瓣膜的有前途的方法。