Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host's immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to design synthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.

中文翻译：

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抗菌宿主防御肽：功能和临床潜力。

阳离子宿主防御肽（CHDP），也称为抗菌肽，是天然存在的肽，可通过其直接的杀微生物特性和/或通过影响宿主的免疫反应来抵抗感染。CHDP控制感染以及解决有害炎症的独特能力引起了人们对利用这些肽的特性来开发传染病，慢性炎性疾病和伤口愈合新疗法的兴趣。已经使用了各种策略来设计合成优化的肽，其毒性可以忽略不计。在这里，我们关注于了解CHDP功能范围以及基于CHDP疗法的新兴潜在临床应用方面取得的进展。