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4-(4-Chloro-2-oxo-3(1H-phenanthro[9,10-d]imidazol-2-yl)-2H-chromen-6-yl) benzaldehyde as a fluorescent probe for medical imaging: linear and nonlinear optical properties
Photochemical & Photobiological Sciences ( IF 3.1 ) Pub Date : 2020-02-27 , DOI: 10.1039/c9pp00478e
Przemysław Krawczyk 1, 2, 3, 4, 5
Affiliation  

This study presents the full theoretical optical and biological characteristics of a new fluorescent probe based on the phenanthroimidazole backbone (PB5). The aldehyde group was selected as the active group to bind to the protein during conjugation. The new fluorescent probe is based on the phenanthroimidazole backbone; however, unlike previously presented works, as the chromophore part, it contains the first introduction of the 4-chloro-2H-chromen-2-one part. In order to achieve the best cognitive aspect, the study included not only the dye itself but also the concanavalin A conjugate. The linear and non-linear optical properties and biological activities described in this study clearly indicate that the presented dye is a promising material as a fluorescent probe in medical imaging.

中文翻译:

4-(4-氯-2-氧代-3(1H-菲[9,10-d]咪唑-2-基)-2H-铬-6-基)苯甲醛作为医学成像的荧光探针:线性和非线性光学性质

这项研究介绍了基于菲并咪唑骨架(PB5)的新型荧光探针的完整理论光学和生物学特性。选择醛基作为结合过程中与蛋白质结合的活性基团。新的荧光探针基于菲并咪唑骨架。然而,与先前介绍的作品不同,它是发色团的一部分,它首次引入了4-chloro-2 H -chromen-2-one部分。为了获得最佳的认知方面,该研究不仅包括染料本身,还包括伴刀豆球蛋白A缀合物。这项研究中描述的线性和非线性光学性质和生物学活性清楚地表明,所提出的染料是医学成像中作为荧光探针的有前途的材料。
更新日期:2020-02-27
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