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Men’s age at first birth and alcohol-related morbidity and mortality among siblings
Drug and Alcohol Dependence ( IF 4.2 ) Pub Date : 2020-02-27 , DOI: 10.1016/j.drugalcdep.2020.107942
Elina Einiö , Elina Hiltunen , Pekka Martikainen , Kaarina Korhonen

Background

Men’s age at first birth may negatively or positively affect alcohol-related morbidity and mortality, although little evidence is available.

Methods

We used register data of over 22,000 brothers to analyze the associations between age at first birth and alcohol-related morbidity and mortality from the age of 35 until the age of 60 or 72. We employed conventional Cox models and inter-sibling models, which allowed adjustment for unobserved social and genetic characteristics shared by brothers.

Results

The findings show that men’s age at first birth was inversely associated with alcohol-related morbidity and mortality, independent of unobserved characteristics shared by brothers and of observed demographic confounders. Men who had their first child late at 35–45 years experienced lower alcohol-related morbidity and mortality (hazard ratio (HR) = 0.57, 95% confidence interval (CI) = 0.43, 0.75) than men who had their first child at 25–29. Men who had their first child before age 20 had the highest morbidity and mortality among all fathers (HR = 1.36, 95% CI = 1.09, 1.69), followed by men who had their child at 20–24 (HR = 1.12, 95% CI = 1.00, 1.25).

Conclusions

The results imply that the inverse association between men’s age at first birth and alcohol-related morbidity and mortality is not driven by familial characteristics.



中文翻译:

兄弟姐妹中男性的首次出生年龄和与酒精有关的发病率和死亡率

背景

男性的一胎年龄可能对酒精相关的发病率和死亡率产生负面或正面影响,尽管目前尚无证据。

方法

我们使用了超过22,000个兄弟的注册数据来分析从35岁到60或72岁的初生年龄与酒精相关的发病率和死亡率之间的关联。我们采用了传统的Cox模型和同胞模型,调整兄弟俩共同的未观察到的社会和遗传特征。

结果

研究结果表明,男性的一胎年龄与酒精相关的发病率和死亡率成反比,而与兄弟姐妹和观察到的人口混杂因素的共同特征无关。与第一个孩子25岁的男性相比,第一个孩子年龄在35-45岁的男性与酒精相关的发病率和死亡率较低(危险比(HR)= 0.57,95%的置信区间(CI)= 0.43,0.75) –29。在20岁之前生下第一胎的男人在所有父亲中发病率和死亡率最高(HR = 1.36,95%CI = 1.09,1.69),其次是在20-24岁之间生孩子的男人(HR = 1.12,95% CI = 1.00,1.25)。

结论

结果表明,男性初生年龄与酒精相关的发病率和死亡率之间的负相关关系不受家族特征的驱动。

更新日期:2020-02-27
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