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Investigation of phase-contrast magnetic resonance imaging underestimation of turbulent flow through the aortic valve phantom: experimental and computational study using lattice Boltzmann method.
Magnetic Resonance Materials in Physics Biology and Medicine ( IF 2.3 ) Pub Date : 2020-02-27 , DOI: 10.1007/s10334-020-00837-5
Radek Fučík 1 , Radek Galabov 1, 2 , Petr Pauš 1 , Pavel Eichler 1 , Jakub Klinkovský 1 , Robert Straka 1, 3 , Jaroslav Tintěra 2 , Radomír Chabiniok 1, 4, 5, 6, 7
Affiliation  

OBJECTIVE The accuracy of phase-contrast magnetic resonance imaging (PC-MRI) measurement is investigated using a computational fluid dynamics (CFD) model with the objective to determine the magnitude of the flow underestimation due to turbulence behind a narrowed valve in a phantom experiment. MATERIALS AND METHODS An acrylic stationary flow phantom is used with three insertable plates mimicking aortic valvular stenoses of varying degrees. Positive and negative horizontal fluxes are measured at equidistant slices using standard PC-MRI sequences by 1.5T and 3T systems. The CFD model is based on the 3D lattice Boltzmann method (LBM). The experimental and simulated data are compared using the Bland-Altman-derived limits of agreement. Based on the LBM results, the turbulence is quantified and confronted with the level of flow underestimation. RESULTS LBM gives comparable results to PC-MRI for valves up to moderate stenosis on both field strengths. The flow magnitude through a severely stenotic valve was underestimated due to signal void in the regions of turbulent flow behind the valve, consistently with the level of quantified turbulence intensity. DISCUSSION Flow measured by PC-MRI is affected by noise and turbulence. LBM can simulate turbulent flow efficiently and accurately, it has therefore the potential to improve clinical interpretation of PC-MRI.

中文翻译:

通过主动脉瓣模型的湍流的相位对比磁共振成像低估的研究:使用格子 Boltzmann 方法的实验和计算研究。

目的 使用计算流体动力学 (CFD) 模型研究相衬磁共振成像 (PC-MRI) 测量的准确性,目的是确定由于在体模实验中狭窄阀门后面的湍流而导致的流量低估幅度。材料和方法 丙烯酸固定流动模型与三个可插入的板一起使用,模拟不同程度的主动脉瓣狭窄。使用标准 PC-MRI 序列通过 1.5T 和 3T 系统在等距切片上测量正负水平通量。CFD 模型基于 3D 晶格玻尔兹曼方法 (LBM)。使用 Bland-Altman 导出的一致性极限比较实验和模拟数据。基于 LBM 结果,湍流被量化并面临流量低估的水平。结果 LBM 在两种场强下,对于中度狭窄的瓣膜,其结果与 PC-MRI 相当。由于阀门后面湍流区域的信号无效,通过严重狭窄阀门的流量大小被低估了,这与量化的湍流强度水平一致。讨论 PC-MRI 测量的流量受噪声和湍流的影响。LBM 可以高效准确地模拟湍流,因此具有改善 PC-MRI 临床解释的潜力。讨论 PC-MRI 测量的流量受噪声和湍流的影响。LBM 可以高效准确地模拟湍流,因此具有改善 PC-MRI 临床解释的潜力。讨论 PC-MRI 测量的流量受噪声和湍流的影响。LBM 可以高效准确地模拟湍流,因此具有改善 PC-MRI 临床解释的潜力。
更新日期:2020-04-22
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