In the study presented in this issue of the European Respiratory Journal, Brinkman et al. [1] investigated the link between traces of asthma medication in urine of severe asthmatic patients and exhaled volatile organic compounds (VOCs). One potential application of this study in clinical practice would be an easy, indirect measurement of compliance using detection of exhaled breath biomarkers resulting from metabolism and excretion of medications by the lungs. VOCs are surrogate markers for salbutamol and OCS use, which are part of the definition of poor asthma control. This suggests that VOCs are promising biomarkers that could possibly be used to detect poor adherence to inhaled therapy. http://bit.ly/2SgE44R

中文翻译：

---

呼出挥发性有机化合物以更好地控制哮喘：它会成为未来的无创依从性测试吗？

在本期《欧洲呼吸杂志》上发表的研究中，Brinkman 等人。[1] 调查了严重哮喘患者尿液中的哮喘药物痕迹与呼出的挥发性有机化合物 (VOC) 之间的联系。这项研究在临床实践中的一个潜在应用是使用检测由肺部代谢和排泄药物产生的呼出气生物标志物来简单、间接地测量依从性。VOC 是沙丁胺醇和 OCS 使用的替代标志物，它们是哮喘控制不佳定义的一部分。这表明 VOC 是很有前景的生物标志物，可用于检测对吸入疗法依从性不佳的情况。http://bit.ly/2SgE44R