Previous research suggests that omega-3 fatty acids from animal origin may promote the browning of subcutaneous white adipose tissue. We evaluated if supplementation with a plant oil (chia, Salvia hispanica L.) rich in alpha-linolenic fatty acid (C18:3; ω-3) would promote browning and improve glucose metabolism in animals subjected to an obesogenic diet. Swiss male mice (n = 28) were divided into 4 groups: C: control diet; H: high-fat diet; HC: animals in the H group supplemented with chia oil after reaching obesity; HCW: animals fed since weaning on a high-fat diet supplemented with chia oil. Glucose tolerance, inflammatory markers, and expression of genes and proteins involved in the browning process were examined. When supplemented since weaning, chia oil improved glucose metabolism and promoted the browning process and a healthier phenotype. Results of this study suggested that chia oil has potential to protect against the development of obesity-related diseases.

中文翻译：

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Chia油在高脂饮食诱导的肥胖小鼠中诱导白色脂肪组织褐变。

先前的研究表明，动物来源的omega-3脂肪酸可能会促进皮下白色脂肪组织的褐变。我们评估了补充富含α-亚麻酸脂肪酸（C18：3;ω-3）的植物油（奇亚，丹参，丹参）是否会促进褐变并改善接受致肥胖饮食的动物的葡萄糖代谢。瑞士雄性小鼠（n = 28）分为4组：C：对照饮食；H：高脂饮食；HC：H组动物在肥胖后补充了奇亚油；HCW：断奶后进食高脂饮食并加有奇亚油的动物。检查了糖耐量，炎症标记以及褐变过程中涉及的基因和蛋白质的表达。自断奶后补充，正大油可改善葡萄糖代谢，促进褐变过程和更健康的表型。