Thienopyrimidines are popular purine bioisosteres, a fundamental piece of the human metabolome. The structural similarity of this scaffold with nucleobases in the nucleic acid of DNA made it an interesting moiety to be used in the design of kinase inhibitors. This review focuses on the chemistry of thieno[2,3‐d]pyrimidine derivatives and their potential activities against Fms‐like tyrosine kinase (FLT3kinase) in addition to their structure‐activity relationship studies.

中文翻译：

---

Thieno [2,3-d]嘧啶衍生物：合成方法及其FLT3激酶抑制作用

噻吩并嘧啶是流行的嘌呤生物等排体，是人类代谢组学的基本组成部分。该支架与DNA核酸中的核碱基的结构相似性使其成为在激酶抑制剂设计中使用的有趣部分。除了结构-活性关系研究以外，本综述着重于噻吩并[2,3-d]嘧啶衍生物的化学及其对Fms样酪氨酸激酶（FLT3激酶）的潜在活性。