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Endothelial and Inflammation Biomarker Profiles at Diagnosis Reflecting Clinical Heterogeneity and Serving as a Prognostic Tool for Treatment Response in Two Independent Cohorts of Patients With Juvenile Dermatomyositis.
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2020-02-26 , DOI: 10.1002/art.41236
Judith Wienke 1 , Lauren M Pachman 2 , Gabrielle A Morgan 2 , Joo Guan Yeo 3 , Maria C Amoruso 2 , Victoria Hans 2 , Sylvia S M Kamphuis 4 , Esther P A H Hoppenreijs 5 , Wineke Armbrust 6 , J Merlijn van den Berg 7 , Petra C E Hissink Muller 8 , Kyra A Gelderman 9 , Thaschawee Arkachaisri 3 , Femke van Wijk 1 , Annet van Royen-Kerkhof 1
Affiliation  

Juvenile dermatomyositis (DM ) is a heterogeneous systemic immune‐mediated vasculopathy. This study was undertaken to 1) identify inflammation/endothelial dysfunction–related biomarker profiles reflecting disease severity at diagnosis, and 2) establish whether such biomarker profiles could be used for predicting the response to treatment in patients with juvenile DM .

中文翻译:

诊断时的内皮和炎症生物标志物概况反映了临床异质性,并作为两个独立队列的青少年皮肌炎患者的治疗反应的预后工具。

少年皮肌炎(DM)是一种异质性全身免疫介导的血管病。进行这项研究的目的是:1)确定与炎症/内皮功能障碍相关的生物标志物谱,以反映诊断时的疾病严重程度,以及2)确定这种生物标志物谱是否可用于预测DM患者的治疗反应。
更新日期:2020-02-26
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