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Structural Insights into the Activation of mTORC1 on the Lysosomal Surface.
Trends in Biochemical Sciences ( IF 13.8 ) Pub Date : 2020-02-27 , DOI: 10.1016/j.tibs.2020.02.004
Jin H Park 1 , Gina Lee 1 , John Blenis 1
Affiliation  

Using cryo-electron microscopy and molecular characterization, David Sabatini and colleagues provide crucial new insights that validate and expand their model of how amino acids are sensed and signal at the lysosome to activate mechanistic target of rapamycin complex 1 (mTORC1) and cell growth-regulating processes. This work also reveals new therapeutic opportunities for mTORC1-driven diseases.

中文翻译:

溶酶体表面上mTORC1激活的结构见解。

使用冷冻电子显微镜和分子表征,David Sabatini及其同事提供了至关重要的新见解,这些见解可验证和扩展他们关于如何感测氨基酸并在溶酶体处发出信号的模型,以激活雷帕霉素复合物1(mTORC1)的机械靶标和调节细胞生长流程。这项工作还揭示了mTORC1驱动疾病的新治疗机会。
更新日期:2020-02-27
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