Three undescribed sesquiterpene lactones (1-3), 1β,4β-dihydroxy-guaia-10(14),11(13)-dien-8α,12-olide (1), 4α, 6α-dihydroxy-9β,10β-epoxy-1βH-guaia-11(13)-en-8α,12-olide (2), and 4α,9β-dihydroxy-6α-acetoxy-1βH-guaia-10(14),11(13)-dien-8α,12-olide (3), as well as a known sesquiterpene lactone, (4α,5α,8β,10α)-4,10-dihydroxy-1,11(13)-guaiadien-12,8-olide (4), along with a lignan, pinoresinol (5), a flavonoid, chrysosplenol C (6), and two triterpenes, a mixture of isomers, taraxasterol acetate and Ψ-taraxasterol acetate (7a/7b), and a mixture of isomers taraxasterol and Ψ-taraxasterol (8a/8b) were isolated from the aerial parts of Chrysophthalmum montanum (DC.) Boiss. The structures of 1-6, 7a/7b, and 8a/8b were established on the basis of spectroscopic evidence, such as MS, NMR, UV, and IR spectroscopy. All isolated compounds, except for 5 and 8a/8b, were assayed for their antiproliferative activities against three human cancer cell lines, i.e. cervical (HeLa), breast (MCF-7), and lung (A549), and a normal human lung cell line (BEAS-2B) using MTT method. Compounds 1, 4, and 6 showed significant inhibitory effects on cancer cell growth at 20 μg/mL concentration, with cell viability ranging from 53 to 64 % against MCF-7 cell line. In addition, compounds 4, and 6 exhibited cytotoxicity against HeLa cancer cell line with the viability of approximately 64 %. In conclusion, compounds 1, 4, and 6 may serve as leads for further research towards the development of anticancer agents.

三个未描述的倍半萜内酯（13），1个β，4 β -二羟基guaia-10（14），11（13） -二烯8 α，12-内酯（1），4 α，6 α -二羟基9 β，10 β -环氧-1 β H-guaia-11（13） -烯8 α，12-内酯（2）和4 α，9 β -二羟基-6- α -乙酰氧基-1- β H-guaia -10（14），11（13） -二烯8 α，12-内酯（3），以及已知的倍半萜内酯，（4 α，5 α，8β，10 α）-4,10-二羟基-1,11-（13）-guaiadien-12,8内酯（4），以及木脂素，松脂醇（5），类黄酮，chrysosplenol C（6），和2三萜类，异构体，蒲公英乙酸乙酯和的混合物Ψ -taraxasterol乙酸乙酯（7A / 7B），和异构体的蒲公英和混合物Ψ -taraxasterol（8A / 8B）从的地上部分分离Chrysophthalmum montanum（DC。）羌活。的结构1 - ，7A / 7B 6和8A / 8B质谱是根据光谱学证据（例如MS，NMR，UV和IR光谱学）建立的。除5和8a / 8b外，所有分离的化合物均针对三种人类癌细胞系，即宫颈（HeLa），乳腺癌（MCF-7）和肺（A549）和正常人类肺细胞的抗增殖活性进行了测定。线（BEAS-2B）使用MTT方法。化合物1，4，和6显示出对癌细胞生长显著抑制作用在20μg/ mL的浓度，与细胞生存力从53％至64％对MCF-7细胞系。此外，化合物4和6表现出对HeLa癌细胞系的细胞毒性，存活率约为64％。总之，化合物1，4，和6可以用作引线用于向抗癌剂的开发进一步的研究。