Oxidative stress is a common feature of genetic and idiopathic neurological diseases that thus far have been intractable to drug therapy. Polyunsaturated fatty acids (PUFAs) form cellular, mitochondrial, retinal, and other membranes highly important in neuronal function. However, PUFAs are susceptible to the noxious lipid peroxidation (LPO) chain reaction, which is a common feature of various neurological and age-related pathologies, making this pathway an attractive target for therapeutic intervention. Regioselective deuteration that reinforces oxidation-prone, bis-allylic sites of PUFAs is a novel, nonantioxidant treatment modality that dramatically reduces LPO, potentially mitigating numerous diseases through preservation of membrane properties and amelioration of oxidative stress. Animal disease models and several ongoing human clinical trials highlight the potential of the deuterated-PUFA (D-PUFA) drug candidates currently in development.

中文翻译：

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抗神经变性的多不饱和脂肪酸氘化。

氧化应激是遗传性和特发性神经系统疾病的一个共同特征，迄今为止，这种疾病对于药物治疗来说是难以解决的。多不饱和脂肪酸（PUFA）形成了细胞，线粒体，视网膜和其他在神经元功能中非常重要的膜。但是，PUFA易受有害脂质过氧化（LPO）链反应的影响，这是各种神经系统疾病和与年龄有关的病理学的共同特征，使该途径成为治疗干预的有吸引力的靶标。区域选择性氘化增强了PUFAs易氧化的双烯丙基位点，是一种新颖的非抗氧化剂治疗方式，可显着降低LPO，可通过保留膜特性和减轻氧化应激来缓解多种疾病。