ABSTRACT Serum Albumins are the most abundant transport protein and they are important in the transport and delivery of small molecules and drugs to different parts of the body. Their binding with various ligand molecules has an important role in the pharmaco-kinetic behavior of these molecules. Plant derived natural molecules; flavonoids, alkaloids, stilbenes and coumarins, possess valuable pharmacological and therapeutic potentials. Their interaction with serum albumins is an area of interest for many researchers. This article reviews the interaction of flavonoids, alkaloids, stilbenes and coumarins with human and bovine serum albumins studied using various spectroscopic techniques such as uv-visible absorption, fluorescence, circular dichroism (CD), Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR) spectroscopy and molecular modeling methods. The present review will throw light on selecting, designing and optimizing these molecules for biomedical applications which can selectively target their binding sites.

中文翻译：

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血清白蛋白与植物来源的天然分子相互作用的光谱研究

摘要 血清白蛋白是最丰富的转运蛋白，它们在小分子和药物向身体不同部位的转运和递送中起着重要作用。它们与各种配体分子的结合在这些分子的药代动力学行为中具有重要作用。植物来源的天然分子；类黄酮、生物碱、芪和香豆素具有宝贵的药理和治疗潜力。它们与血清白蛋白的相互作用是许多研究人员感兴趣的领域。本文综述了黄酮类化合物、生物碱、芪和香豆素与使用各种光谱技术研究的人和牛血清白蛋白的相互作用，如紫外-可见吸收、荧光、圆二色性 (CD)、傅里叶变换红外 (FTIR)、核磁共振 (NMR) 光谱和分子建模方法。本综述将为生物医学应用选择、设计和优化这些分子，这些分子可以选择性地靶向其结合位点。