Background

It is well established that asthma is common in patients with atopic dermatitis (AD).

Objectives

We performed a systematic review and meta-analysis to determine the prevalence of asthma and respiratory symptoms in individuals with AD as well as the association between AD and asthma.

Methods

At least 2 authors independently searched the medical databases PubMed, EMBASE, LILACS, and SCOPUS for all English-language studies with data on asthma prevalence among patients with AD or the association between AD and asthma. Pooled odds ratios with 95% confidence intervals (CIs) and pooled proportions were estimated with random-effects models. The Newcastle-Ottawa scale was used to assess study quality.

Results

The search yielded 39,503 articles. Of these, 213 studies were included in a quantitative analysis. The overall pooled prevalence of asthma was 25.7% (95% CI, 23.7-27.7) in patients with AD and 8.1% (95% CI, 7.0-9.4) among reference individuals. There was a significant association between AD and asthma when compared with reference individuals (odds ratio, 3.03; 95% CI, 2.64-3.47).

Limitations

The definitions of AD and asthma differed across the included studies and varied from self-report to physician diagnosed.

Conclusions

Asthma is a common comorbidity of AD. Physicians should be cognizant of this relationship and address asthma symptoms in their patients.

中文翻译：

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特应性皮炎患者哮喘的患病率：系统评价和荟萃分析。

背景

众所周知，哮喘在特应性皮炎 (AD) 患者中很常见。

目标

我们进行了系统回顾和荟萃分析，以确定 AD 患者中哮喘和呼吸道症状的患病率以及 AD 与哮喘之间的关联。

方法

至少有 2 位作者独立检索了医学数据库 PubMed、EMBASE、LILACS 和 SCOPUS，以获取有关 AD 患者哮喘患病率或 AD 与哮喘之间关联数据的所有英语研究。使用随机效应模型估计具有 95% 置信区间 (CI) 的汇总优势比和汇总比例。纽卡斯尔-渥太华量表用于评估研究质量。

结果

搜索产生了 39,503 篇文章。其中，213 项研究被纳入定量分析。AD 患者中哮喘的总体汇总患病率为 25.7%（95% CI，23.7-27.7），参考个体中为 8.1%（95% CI，7.0-9.4）。与参考个体相比，AD 和哮喘之间存在显着关联（优势比，3.03；95% CI，2.64-3.47）。

限制

AD 和哮喘的定义在纳入的研究中有所不同，从自我报告到医生诊断都有所不同。

结论

哮喘是 AD 的常见合并症。医生应该认识到这种关系并解决患者的哮喘症状。