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The effect of vitamin d-calcium co-supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials
Cytokine ( IF 3.8 ) Pub Date : 2020-05-01 , DOI: 10.1016/j.cyto.2020.155050
Omid Asbaghi 1 , Mehdi Sadeghian 2 , Hassan Mozaffari-Khosravi 3 , Vahid Maleki 4 , Azad Shokri 5 , Fatemeh Hajizadeh-Sharafabad 4 , Mohammad Alizadeh 6 , Omid Sadeghi 7
Affiliation  

Data on the effect of vitamin d-calcium co-supplementation on inflammatory biomarkers, compared to placebo or intake of calcium and vitamin D supplements alone, are conflicting. The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize available findings on the effect of vitamin d-calcium co-supplementation on inflammatory biomarkers in adults. Online databases including PubMed, Scopus, ISI Web of Science and Google Scholar were searched using relevant keywords up to June 2019. We included RCTs investigating the effect of vitamin d-calcium co-supplementation, compared to placebo or intake of calcium and vitamin D supplements alone, on inflammatory biomarkers. In total, 8 RCTs that enrolled 706 participants, aged ≥18 years, were included. Pooling 9 effect sizes from 8 RCTs on C-reactive protein (CRP) levels revealed a significant reducing effect of vitamin d-calcium co-supplementation on serum CRP concentrations compared to placebo intake (WMD: -0.82, 95% CI: -1.56, -0.07 mg/L, P = 0.03). However, this beneficial effect became non-significant when compared to the intake of calcium and vitamin D supplements alone. Also, we found that the associations of vitamin d-calcium dosages and duration of intervention with the reduction in CRP concentrations were in a non-linear fashion. Combining 5 effect sizes for IL-6 and 3 effect sizes for TNF-α, we found no significant effect of joint calcium and vitamin D supplementation on serum concentrations of IL-6 (WMD: -1.45, 95% CI: -5.31, 2.41 pg/mL, P = 0.46) and TNF-α (WMD: -0.79, 95% CI: -2.19, 0.61 pg/mL, P = 0.26). We found a beneficial effect of vitamin d-calcium co-supplementation on serum CRP concentrations. However, such a beneficial effect was not seen for IL-6 and TNF-α concentrations.

中文翻译:

维生素 d-钙联合补充剂对炎症生物标志物的影响:随机对照试验的系统评价和荟萃分析

与安慰剂或单独摄入钙和维生素 D 补充剂相比,维生素 d-钙联合补充剂对炎症生物标志物的影响的数据是相互矛盾的。目前对随机对照试验 (RCT) 的系统评价和荟萃分析旨在总结关于维生素 d-钙联合补充剂对成人炎症生物标志物影响的现有发现。截至 2019 年 6 月,使用相关关键词搜索了包括 PubMed、Scopus、ISI Web of Science 和 Google Scholar 在内的在线数据库。仅针对炎症生物标志物。总共纳入了 8 项 RCT,共招募了 706 名年龄≥18 岁的参与者。将 8 个 RCT 对 C 反应蛋白 (CRP) 水平的 9 个效应大小汇总显示,与摄入安慰剂相比,维生素 d-钙联合补充剂对血清 CRP 浓度的影响显着降低(WMD:-0.82,95% CI:-1.56, -0.07 毫克/升,P = 0.03)。然而,与单独摄入钙和维生素 D 补充剂相比,这种有益效果变得不显着。此外,我们发现维生素 d-钙剂量和干预持续时间与 CRP 浓度降低的关联呈非线性。结合 IL-6 的 5 个效应量和 TNF-α 的 3 个效应量,我们发现联合补充钙和维生素 D 对 IL-6 的血清浓度没有显着影响(WMD:-1.45,95% CI:-5.31,2.41 pg/mL,P = 0.46)和 TNF-α(WMD:-0.79,95% CI:-2.19,0.61 pg/mL,P = 0.26)。我们发现维生素 d-钙联合补充剂对血清 CRP 浓度有益。然而,对于 IL-6 和 TNF-α 浓度没有观察到这种有益效果。
更新日期:2020-05-01
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