Autophagy is an intracellular degradation pathway that is highly conserved during the evolution of eukaryotes and is based on lysosome. Under nutritional deficiencies or stress, cells can clear damaged and necrotic organelles and proteins through autophagy to maintain the homeostasis of cells and organisms. Studies have found that abnormal autophagy is closely related to the occurrence and development of neurodegenerative diseases and tumors. In order to further understand the relationship between lysosomes and autophagy, tumorigenesis and drug resistance, the role of autophagy-lysosomal pathway in tumor resistance and related mechanisms and the relationship between drug resistance and hypoxia-induced autophagy are discussed in this paper.

中文翻译：

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自噬-溶酶体途径对肿瘤耐药性影响的研究进展。

自噬是一种细胞内降解途径，在真核生物的进化过程中高度保守，并基于溶酶体。在营养不足或压力下，细胞可以通过自噬清除受损和坏死的细胞器和蛋白质，以维持细胞和生物体的体内平衡。研究发现异常的自噬与神经退行性疾病和肿瘤的发生和发展密切相关。为了进一步了解溶酶体与自噬，肿瘤发生和耐药的关系，本文讨论了自噬-溶酶体途径在肿瘤耐药中的作用及相关机制，以及耐药与缺氧诱导的自噬之间的关系。