当前位置: X-MOL 学术Gut › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Detection of Barrett’s oesophagus through exhaled breath using an electronic nose device
Gut ( IF 24.5 ) Pub Date : 2020-02-25 , DOI: 10.1136/gutjnl-2019-320273
Yonne Peters 1 , Ruud W M Schrauwen 2 , Adriaan C Tan 3 , Sanne K Bogers 2 , Bart de Jong 1 , Peter D Siersema 4
Affiliation  

Timely detection of oesophageal adenocarcinoma (OAC) and even more so its precursor Barrett’s oesophagus (BO) could contribute to decrease OAC incidence and mortality. An accurate, minimally-invasive screening method for BO for widespread use is currently not available. In a proof-of-principle study in 402 patients, we developed and cross-validated a BO prediction model using volatile organic compounds (VOCs) analysis with an electronic nose device. This electronic nose was able to distinguish between patients with and without BO with good diagnostic accuracy (sensitivity 91% specificity 74%) and seemed to be independent of proton pump inhibitor use, the presence of hiatal hernia, and reflux. This technique may enable an efficient, well-tolerated, and sensitive and specific screening method to select high-risk individuals to undergo upper endoscopy.

中文翻译:

使用电子鼻装置通过呼出气检测巴雷特食管

及时发现食管腺癌 (OAC) 及其前体巴雷特食管 (BO) 可能有助于降低 OAC 的发病率和死亡率。目前还没有广泛使用的准确、微创的 BO 筛查方法。在一项对 402 名患者进行的原理验证研究中,我们使用电子鼻设备对挥发性有机化合物 (VOC) 进行分析,开发并交叉验证了 BO 预测模型。这种电子鼻能够以良好的诊断准确性(敏感性 91% 特异性 74%)区分有无 BO 的患者,并且似乎与质子泵抑制剂的使用、食管裂孔疝的存在和反流无关。这种技术可以实现高效的、耐受良好的、
更新日期:2020-02-25
down
wechat
bug