BACKGROUND This study aimed to assess the role of fibrinogen (Fib) to albumin (ALB) ratio (FAR) in ankylosing spondylitis (AS) and its association with disease activity. METHODS 135 AS patients and 76 age - and gender - matched healthy controls were collected in this retrospective study. Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score was used to divide the AS patients into remission group (BASDAI < 4) and active group (BASDAI ≥ 4). The association between FAR and BASDAI was evaluated by Spearman correlation. Receiver operating characteristic (ROC) curve was made to determine the area under curve (AUC) value. The prognostic value of FAR in the AS disease activity was tested by multivariate logistical regression analyses. RESULTS AS patients showed higher FAR levels than the controls (P < 0.001). FAR was also increased in active group of AS patients than those in inactive group (P < 0.001). Spearman analyses showed that FAR was positively related with BASDAI (r = 0.594, P < 0.001) in AS patients. ROC curve analyses revealed that the AUC of FAR was higher than ALB and Fib. In addition, the optimal cutoff value of FAR for AS diagnosis was 78.84, with a specificity of 88.2% and sensitivity of 77.0%. Logistical regression analyses showed that FAR (odds ratio = 13.091, 95% confidence interval: 4.686-36.571, P < 0.001) was a predictor for AS disease activity. CONCLUSIONS FAR was increased in AS and may act as a novel inflammatory parameter for mirroring disease activity in AS.

中文翻译：

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纤维蛋白原与白蛋白比例在强直性脊柱炎中的作用：与疾病活动的相关性。

背景技术本研究旨在评估纤维蛋白原（Fib）与白蛋白（ALB）的比率（FAR）在强直性脊柱炎（AS）中的作用及其与疾病活动的关系。方法这项回顾性研究收集了135名AS患者和76名年龄和性别匹配的健康对照。使用巴斯强直性脊柱炎疾病活动指数（BASDAI）评分将AS患者分为缓解组（BASDAI <4）和活动组（BASDAI≥4）。通过Spearman相关性评估FAR和BASDAI之间的关联。制作接收机工作特性（ROC）曲线以确定曲线下面积（AUC）值。FAR在AS疾病活动中的预后价值通过多元Logistic回归分析进行了检验。结果AS患者的FAR水平高于对照组（P <0.001）。活动期AS患者的FAR也比不活动组增加（P <0.001）。Spearman分析表明，AS患者中FAR与BASDAI正相关（r = 0.594，P <0.001）。ROC曲线分析表明，FAR的AUC高于ALB和Fib。另外，用于AS诊断的FAR的最佳临界值为78.84，特异性为88.2％，敏感性为77.0％。Logistic回归分析表明，FAR（优势比= 13.091，95％置信区间：4.686-36.571，P <0.001）是AS疾病活动的预测因子。结论FAR在AS中增加，并且可以作为反映AS中疾病活动的新的炎症参数。001）在AS患者中。ROC曲线分析表明，FAR的AUC高于ALB和Fib。另外，用于AS诊断的FAR的最佳临界值为78.84，特异性为88.2％，敏感性为77.0％。Logistic回归分析表明，FAR（优势比= 13.091，95％置信区间：4.686-36.571，P <0.001）是AS疾病活动的预测因子。结论FAR在AS中增加，并且可以作为反映AS中疾病活动的新的炎症参数。001）在AS患者中。ROC曲线分析表明，FAR的AUC高于ALB和Fib。另外，用于AS诊断的FAR的最佳临界值为78.84，特异性为88.2％，敏感性为77.0％。Logistic回归分析表明，FAR（优势比= 13.091，95％置信区间：4.686-36.571，P <0.001）是AS疾病活动的预测因子。结论FAR在AS中增加，并且可以作为反映AS中疾病活动的新的炎症参数。001）是AS疾病活动的预测因子。结论FAR在AS中增加，并且可以作为反映AS中疾病活动的新的炎症参数。001）是AS疾病活动的预测因子。结论FAR在AS中增加，并且可以作为反映AS中疾病活动的新的炎症参数。