当前位置: X-MOL 学术Cell Syst. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Keeping the Proportions of Protein Complex Components in Check.
Cell Systems ( IF 9.3 ) Pub Date : 2020-02-26 , DOI: 10.1016/j.cels.2020.01.004
James Christopher Taggart 1 , Henrik Zauber 2 , Matthias Selbach 2 , Gene-Wei Li 1 , Erik McShane 3
Affiliation  

How do cells maintain relative proportions of protein complex components? Advances in quantitative, genome-wide measurements have begun to shed light onto the roles of protein synthesis and degradation in establishing the precise proportions in living cells: on the one hand, ribosome profiling studies indicate that proteins are already produced in the correct relative proportions. On the other hand, proteomic studies found that many complexes contain subunits that are made in excess and subsequently degraded. Here, we discuss these seemingly contradictory findings, emerging principles, and remaining open questions. We conclude that establishing precise protein levels involves both coordinated synthesis and post-translational fine-tuning via protein degradation.



中文翻译:

控制蛋白质复合物成分的比例。

细胞如何维持蛋白质复合物成分的相对比例?定量,全基因组测量的进展已经开始阐明蛋白质合成和降解在活细胞中建立精确比例的作用:一方面,核糖体谱研究表明蛋白质已经以正确的相对比例产生。另一方面,蛋白质组学研究发现,许多复合物都含有过量制造并随后降解的亚基。在这里,我们讨论这些看似矛盾的发现,新出现的原则以及尚待解决的问题。我们得出结论,建立精确的蛋白质水平涉及通过蛋白质降解的协调合成和翻译后微调。

更新日期:2020-02-26
down
wechat
bug