Introduction

Drug cue reactivity (DCR) is widely used in experimental settings for both assessment and intervention. There is no validated database of pictorial cues available for methamphetamine and opioids.

Methods

360 images in three-groups (methamphetamine, opioid and neutral (control)) matched for their content (objects, hands, faces and actions) were selected in an initial development phase. 28 participants with a history of both methamphetamine and opioid use (37.1 ± 8.11 years old, 12 female) with over six months of abstinence were asked to rate images for craving, valence, arousal, typicality and relatedness.

Results

All drug images were differentiated from neutral images. Drug related images received higher arousal and lower valence ratings compared to neutral images (craving (0-100) for neutral (11.5 ± 21.9), opioid (87.7 ± 18.5) and methamphetamine (88 ± 18), arousal (1-9) for neutral (2.4 ± 1.9), opioid (4.6 ± 2.7) and methamphetamine (4.6 ± 2.6), and valence (1-9) for neutral (4.8 ± 1.3), opioid (4.4 ± 1.9) and methamphetamine (4.4 ± 1.8)). There is no difference between methamphetamine and opioid images in craving, arousal and valence. There is a significant positive relationship between the amount of time that participants spent on drug-related images and the craving they reported for the image. Every 10 points of craving were associated with an increased response time of 383 milliseconds. Three image sets were automatically selected for equivalent fMRI tasks (methamphetamine and opioids) from the database (tasks are available at github).

Conclusion

MOCD provides a resource of validated images/tasks for future DCR studies. Additionally, researchers can select several sets of unique but equivalent images based-on their psychological/physical characteristics for multiple assessments/interventions.

中文翻译：

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甲基苯丙胺和阿片类药物提示数据库（MOCD）：开发和验证

介绍

药物提示反应性（DCR）在实验环境中广泛用于评估和干预。没有经过验证的甲基苯丙胺和阿片类药物的图像提示数据库。

方法

在最初的开发阶段，选择了三组（内容分别为对象，手，脸和动作）匹配的360组图像（甲基苯丙胺，阿片类药物和中性（对照组））。禁酒超过6个月的28名具有甲基苯丙胺和阿片类药物使用史的受试者（37.1±8.11岁，女性12位）被要求对图像的渴望，价，唤醒，典型性和相关性进行评分。

结果

将所有药物图像与中性图像区分开。与药物相关的图像相比，与中性图像相比，中性（11.5±21.9），阿片类药物（87.7±18.5）和甲基苯丙胺（88±18），甲胺（1-9）的中性图像（渴望（0-100））具有更高的唤醒和较低的价数评级。中性（4.8±1.3），阿片类药物（4.4±1.9）和甲基苯丙胺（4.4±1.8），中性（2.4±1.9），阿片类药物（4.6±2.7）和甲基苯丙胺（4.6±2.6）和化合价（1-9）） 。甲基苯丙胺图像和阿片类药物图像之间的渴望，唤醒和化合价没有差异。参与者花在与毒品有关的图像上的时间与其对图像报告的渴望之间存在显着的正相关关系。每10个渴望点就会增加383毫秒的响应时间。

结论

MOCD为将来的DCR研究提供了经过验证的图像/任务资源。此外，研究人员可以根据其心理/生理特征选择几组独特但等效的图像，以进行多次评估/干预。