In the present study, we focused on the solubility of 2-chloromethyl-4-methylquinazoline. By the gravimetric method, the solubility of 2-chloromethyl-4-methylquinazoline was measured in cyclohexane, n-hexane, acetonitrile, tetrahydrofuran, acetone, ethyl acetate, n-propanol, ethanol, isopropanol, and butyl alcohol and in (s) and (cyclohexane + ethyl acetate) binary solvent mixtures from 281.15 to 331.15 K under atmospheric pressure. For all solubility data processing, we used the modified Apelblat model and the Buchowski–Ksiazaczak λh model to fit. For the solubility data of (n-hexane + acetone) and (cyclohexane + ethyl acetate) binary solvent mixtures, two binary solvent fitting models [combined nearly ideal binary solvent/Redlich–Kister (CNIBS/R–K) model and Jouyban–Acree model] and the modified Apelblat model were used to fit. According to the fitting results, it could be seen that the modified Apelblat model had a good correlation with the solubility data of 2-chloromethyl-4-methylquinazoline in both pure and binary solvent systems. The experimental data showed that n-hexane or cyclohexane could be used as effective antisolvents.

中文翻译：

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不同温度下不同溶剂体系中2-氯甲基-4-甲基喹唑啉的溶解度测定和分析（T = 281.15–331.15 K）

在本研究中，我们集中于2-氯甲基-4-甲基喹唑啉的溶解度。通过重量法，2-氯-4-甲基喹唑啉的溶解性在环己烷中进行测定，Ñ己烷，乙腈，四氢呋喃，丙酮，乙酸乙酯，Ñ丙醇，乙醇，异丙醇，和丁醇和（小号）和（环己烷+乙酸乙酯）在大气压下从281.15至331.15 K的二元溶剂混合物。对于所有的溶解度数据处理中，我们使用的改性Apelblat模型和Buchowski-Ksiazaczakλ ħ模型来拟合。对于（n-己烷+丙酮）和（环己烷+乙酸乙酯）二元溶剂混合物，两个二元溶剂拟合模型[结合了近乎理想的二元溶剂/ Redlich–Kister（CNIBS / R–K）模型和Jouyban–Acree模型]和改进的Apelblat模型被用来拟合。根据拟合结果，可以看出，修改后的Apelblat模型与2-氯甲基-4-甲基喹唑啉在纯溶剂系统和二元溶剂系统中的溶解度数据具有良好的相关性。实验数据表明，ñ -己烷或环己烷，可作为有效的抗溶剂。