Breast cancer is the leading cause of cancer-related mortality among women. Early stage diagnosis and treatment of this cancer are crucial to patients’ survival. In addition, it is important to avoid severe side effects during the process of conventional treatments (surgery, chemotherapy, hormonal therapy, and targeted therapy) and increase the patients’ quality of life. Over the past decade, nanomaterials of all kinds have shown excellent prospects in different aspects of oncology. Among them, two-dimensional (2D) nanomaterials are unique due to their physical and chemical properties. The functional variability of 2D nanomaterials stems from their large specific surface area as well as the diversity of composition, electronic configurations, interlayer forces, surface functionalities, and charges. In this review, the current status of 2D nanomaterials in breast cancer diagnosis and therapy is reviewed. In this respect, sensing of the tumor biomarkers, imaging, therapy, and theranostics are discussed. The ever-growing 2D nanomaterials are building blocks for the development of a myriad of nanotheranostics. Accordingly, there is the possibility to explore yet novel properties, biological effects, and oncological applications.

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二维纳米材料在乳腺癌治疗中的应用

乳腺癌是女性癌症相关死亡率的主要原因。该癌症的早期诊断和治疗对患者的生存至关重要。此外，重要的是在常规治疗（手术，化学疗法，激素治疗和靶向治疗）过程中避免严重的副作用，并提高患者的生活质量。在过去的十年中，各种纳米材料在肿瘤学的各个方面都展现出了极好的前景。其中，二维（2D）纳米材料由于其物理和化学特性而非常独特。二维纳米材料的功能变异性来自于它们的大比表面积以及组成，电子结构，层间力，表面功能性和电荷的多样性。在这篇评论中 综述了二维纳米材料在乳腺癌诊断和治疗中的现状。在这方面，讨论了肿瘤生物标志物的感测，成像，治疗和治疗诊断学。不断增长的2D纳米材料是开发多种纳米热力学的基础。因此，有可能探索新颖的性质，生物学效应和肿瘤学应用。