The prevailing sentiment in discussions regarding advances in the treatment of resistant seizures is that we have made little progress over the past 30 years. ^,  Such conclusions are usually based on the fact that the proportion of patients who are rendered seizure free has not increased in decades. Moreover, numerous head-to-head studies have been done with old and new antiseizure medications and most trials have shown no difference in seizure freedom between the groups, albeit sometimes they do show superior tolerability of newer antiseizure medications. The explanation frequently given for this disappointing outcome is that the current animal models often select drugs that have a similar spectrum of activity. The remedy that is often suggested is to use new animal models that could select drugs with novel mechanisms.

中文翻译：

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在过去的30年中，新的抗癫痫药是否改善了临床护理？

关于抗药性癫痫治疗进展的讨论中普遍认为，在过去的30年中，我们取得的进展很小。^， 这些结论通常基于以下事实：几十年来，无癫痫发作的患者比例并未增加。此外，对新旧抗癫痫药物进行了大量的面对面研究，大多数试验表明两组之间的癫痫发作自由度没有差异，尽管有时它们确实显示了较新抗癫痫药物的耐受性。对于这种令人失望的结果经常给出的解释是，当前的动物模型经常选择具有相似活性谱的药物。通常建议的补救措施是使用可以选择具有新机制的药物的新动物模型。