A key feature of macroautophagy/autophagy is the formation of a transient de novo compartment called the phagophore, which envelops cytoplasmic material, ultimately enclosing it within an autophagosome, allowing it to be targeted for degradation. Schütter et al describe a novel mechanism that spatiotemporally coordinates phospholipid synthesis to drive phagophore expansion and autophagosome formation. These authors show that during starvation, fatty acids (FAs) are channeled into phospholipid synthesis, and the newly synthesized lipids are directed toward autophagosome biogenesis.Abbreviations: ACS: acyl-CoA synthetase; ER: endoplasmic reticulum; FA: fatty acid; FAS: fatty acid synthetase; MCS: membrane contact sites; PAS: phagophore assembly site.

中文翻译：

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当您（和何时）喜欢时：按需磷脂合成可在自噬过程中驱动吞噬细胞扩展。

巨噬细胞自噬/自噬的一个关键特征是形成一个称为吞噬细胞的瞬时从头间隔，该间隔将细胞质材料包裹起来，最终将其包裹在自噬体中，使其成为降解的靶标。Schütter等人描述了一种新的机制，该机制在时空上协调磷脂的合成，以驱动吞噬细胞膨胀和自噬体形成。这些作者表明，在饥饿期间，脂肪酸（FAs）被引导进入磷脂合成，而新合成的脂质则直接用于自噬小体的生物发生。缩写：ACS：酰基辅酶A合成酶； ACS：酰基辅酶A。ER：内质网；FA：脂肪酸；FAS：脂肪酸合成酶；MCS：膜接触部位；PAS：荧光体组装现场。