A facile optical sensor for uric acid (UA), an early pathological signature for the metabolic function of humans, was developed based on water-stable coordination polymers (CPs). Herein, three new isostructural fluorescent CPs, [Ln(TCPB)(DMF)₃]_n (Ln = La, CP 1; Ce, CP 2 and Pr, CP 3; H₃TCPB = 1,3,5-tris(1-(2-carboxyphenyl)-1H-pyrazol-3-yl)benzene), with various metal ions were solvothermally synthesized. Significantly, by regulating the metal–organic coordination interactions, the fabricated CP 3 can quantitatively recognize UA with higher sensitivity compared with CP 1 and CP 2. The mechanism for the sensing properties further demonstrates the best performance of CP 3 and the excellent selectivity for UA monitoring. This work represents the strategy of designing fluorescent CP sensors to determine UA and provides a convenient approach for developing analysis platforms for the assessment of related disease progress and human health monitoring.

中文翻译：

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具有协调配位相互作用的三种配位聚合物作为荧光传感器监测嘌呤代谢产物尿酸

基于水稳定配位聚合物（CP），开发了一种简便的光学传感器尿酸（UA），这是人类代谢功能的早期病理特征。在这里，三个新的同构荧光CPs，[Ln（TCPB）（DMF）₃ ] _n（Ln = La，CP 1 ; Ce，CP 2和Pr，CP 3 ; H ₃ TCPB = 1,3,5-tris（1溶剂热合成了具有各种金属离子的-（2-羧基苯基）-1 H-吡唑-3-基）苯。显着地，通过调节金属-有机配位相互作用，与CP 1和CP 2相比，制造的CP 3可以定量识别UA，具有更高的灵敏度。感测特性的机制进一步证明了CP 3的最佳性能和UA监测的出色选择性。这项工作代表了设计荧光CP传感器以确定UA的策略，并为开发用于评估相关疾病进展和人类健康监测的分析平台提供了便捷的方法。