AIM This study aimed to investigate the association of sarcopenia and muscle mass with both peripheral neuropathy and nerve function in type 2 diabetes mellitus. METHODS A total of 1794 patients (937 men and 857 women) with type 2 diabetes, with a mean age of 60.22 years, were enrolled for a cross-sectional study; of these, 183 patients were enrolled for a follow-up study with a median follow-up of 2.7 years. All participants underwent nerve conduction studies and muscle mass index (ASM/HT2) measurements. The composite Z scores for the sensory nerve conduction velocity (SCV) and the motor nerve conduction velocity (MCV) were calculated. The changes in ASM/HT2, SCV, and MCV were calculated from the measurements nearly 2 years apart and classified into three groups: a decrease in ASM/HT2 of >3%, a minor change within ±3%, and an increase in ASM/HT2 of >3%. RESULTS The ASM/HT2 of men was positively associated with the composite Z scores of MCV and SCV, and sarcopenia highly correlated with DPN after adjusting for confounding factors. The optimal cutoff point for ASM/HT2 that indicated DPN was 7.09 kg/m2. Furthermore, increases in ASM/HT2 independently predicted a greater benefit of MCV and SCV increment outcomes, whereas a minor change in ASM/HT2 only significantly associated with lower benefit in terms of SCV increment. However, this phenomenon was not observed in women. CONCLUSIONS Sarcopenia and DPN exhibited a close association. The increased muscle mass improved the partial MCVs and SCVs. However, a sex-related discrepancy was observed in this phenomenon.

中文翻译：

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2型糖尿病患者的肌肉减少症和肌肉质量与周围神经病变和神经功能的关系。

目的本研究旨在探讨2型糖尿病的肌肉减少症和肌肉质量与周围神经病变和神经功能的关系。方法共有1794例2型糖尿病患者（937例男性和857例女性）平均年龄为60.22岁，进行了横断面研究。其中，有183例患者被纳入随访研究，中位随访时间为2.7年。所有参与者都进行了神经传导研究和肌肉质量指数（ASM / HT2）测量。计算感觉神经传导速度（SCV）和运动神经传导速度（MCV）的复合Z评分。ASM / HT2，SCV和MCV的变化是根据相隔近2年的测量值计算得出的，分为三组：ASM / HT2的下降幅度> 3％，微小变化在±3％以内 并且ASM / HT2的增加> 3％。结果男性的ASM / HT2与MCV和SCV的综合Z评分呈正相关，而经调整混杂因素后，肌肉减少症与DPN高度相关。指示DPN的ASM / HT2的最佳临界点为7.09 kg / m2。此外，ASM / HT2的增加独立地预示了MCV和SCV增量结果的更大获益，而ASM / HT2的细微变化仅与SCV增量的较低获益显着相关。但是，在女性中未观察到这种现象。结论肌肉减少症和DPN表现出密切的关联。肌肉质量的增加改善了部分MCV和SCV。但是，在这种现象中观察到性别相关的差异。结果男性的ASM / HT2与MCV和SCV的综合Z评分呈正相关，而经调整混杂因素后，肌肉减少症与DPN高度相关。指示DPN的ASM / HT2的最佳临界点为7.09 kg / m2。此外，ASM / HT2的增加独立地预示了MCV和SCV增量结果的更大获益，而ASM / HT2的细微变化仅与SCV增量的较低获益显着相关。但是，在女性中未观察到这种现象。结论肌肉减少症和DPN表现出密切的关联。肌肉质量的增加改善了部分MCV和SCV。但是，在这种现象中观察到性别相关的差异。结果男性的ASM / HT2与MCV和SCV的综合Z评分呈正相关，而经调整混杂因素后，肌肉减少症与DPN高度相关。指示DPN的ASM / HT2的最佳临界点为7.09 kg / m2。此外，ASM / HT2的增加独立地预示了MCV和SCV增量结果的更大获益，而ASM / HT2的细微变化仅与SCV增量的较低获益显着相关。但是，在女性中未观察到这种现象。结论肌肉减少症和DPN表现出密切的关联。肌肉质量的增加改善了部分MCV和SCV。但是，在这种现象中观察到性别相关的差异。指示DPN的ASM / HT2的最佳临界点为7.09 kg / m2。此外，ASM / HT2的增加独立地预示了MCV和SCV增量结果的更大获益，而ASM / HT2的细微变化仅与SCV增量的较低获益显着相关。但是，在女性中未观察到这种现象。结论肌肉减少症和DPN表现出密切的关联。肌肉质量的增加改善了部分MCV和SCV。但是，在这种现象中观察到性别相关的差异。指示DPN的ASM / HT2的最佳临界点为7.09 kg / m2。此外，ASM / HT2的增加独立地预示了MCV和SCV增量结果的更大获益，而ASM / HT2的细微变化仅与SCV增量的较低获益显着相关。但是，在女性中未观察到这种现象。结论肌肉减少症和DPN表现出密切的关联。肌肉质量的增加改善了部分MCV和SCV。但是，在这种现象中观察到性别相关的差异。结论肌肉减少症和DPN表现出密切的关联。肌肉质量的增加改善了部分MCV和SCV。但是，在这种现象中观察到性别相关的差异。结论肌肉减少症和DPN表现出密切的关联。肌肉质量的增加改善了部分MCV和SCV。但是，在这种现象中观察到性别相关的差异。