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Sarcopenia is attenuated by TRB3 knockout in aging mice via the alleviation of atrophy and fibrosis of skeletal muscles.
Journal of Cachexia, Sarcopenia and Muscle ( IF 8.9 ) Pub Date : 2020-02-25 , DOI: 10.1002/jcsm.12560
Guo-Kai Shang 1 , Lu Han 1, 2 , Zhi-Hao Wang 1, 3 , Ya-Peng Liu 1 , Sen-Bo Yan 1 , Wen-Wen Sai 1 , Di Wang 1 , Yi-Hui Li 1, 4 , Wei Zhang 1 , Ming Zhong 1
Affiliation  

Sarcopenia causes several adverse events in elderly people. Muscle fibre atrophy and interstitial fibrosis are the main histopathological changes in sarcopenia and account for decreased muscle function. Tribbles homologue 3 (TRB3) was previously reported to exhibit age‐related expression and play a vital role in cell proliferation, differentiation, and fibrosis. We aimed to investigate how TRB3 affects sarcopenia.

中文翻译:

通过减轻骨骼肌的萎缩和纤维化,在衰老小鼠中敲除 TRB3 可减轻肌肉减少症。

肌肉减少症会导致老年人出现多种不良事件。肌肉纤维萎缩和间质纤维化是肌肉减少症的主要组织病理学变化,也是肌肉功能下降的原因。Tribbles 同源物 3 (TRB3) 先前被报道表现出与年龄相关的表达,并在细胞增殖、分化和纤维化中发挥重要作用。我们旨在研究 TRB3 如何影响肌肉减少症。
更新日期:2020-02-25
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