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Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2.
Journal of Infection ( IF 28.2 ) Pub Date : 2020-02-25 , DOI: 10.1016/j.jinf.2020.02.017
Yu-Huan Xu 1 , Jing-Hui Dong 1 , Wei-Min An 1 , Xiao-Yan Lv 1 , Xiao-Ping Yin 2 , Jian-Zeng Zhang 1 , Li Dong 3 , Xi Ma 2 , Hong-Jie Zhang 4 , Bu-Lang Gao 1
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PURPOSE To investigate the clinical and imaging characteristics of computed tomography (CT) in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2. MATERIALS AND METHODS A retrospective analysis was performed on the imaging findings of patients confirmed with COVID-19 pneumonia who had chest CT scanning and treatment after disease onset. The clinical and imaging data were analyzed. RESULTS Fifty patients were enrolled, including mild type in nine, common in 28, severe in 10 and critically severe in the rest three. Mild patients (29 years) were significantly (P<0.03) younger than either common (44.5 years) or severe (54.7) and critically severe (65.7 years) patients, and common patients were also significantly (P<0.03) younger than severe and critically severe patients. Mild patients had low to moderate fever (<39.1 °C), 49 (98%) patients had normal or slightly reduced leukocyte count, 14 (28%) had decreased counts of lymphocytes, and 26 (52%) patients had increased C-reactive protein. Nine mild patients were negative in CT imaging. For all the other types of NCP, the lesion was in the right upper lobe in 30 cases, right middle lobe in 22, right lower lobe in 39, left upper lobe in 33 and left lower lobe in 36. The lesion was primarily located in the peripheral area under the pleura with possible extension towards the pulmonary hilum. Symmetrical lesions were seen in 26 cases and asymmetrical in 15. The density of lesion was mostly uneven with ground glass opacity as the primary presentation accompanied by partial consolidation and fibrosis. CONCLUSION CT imaging presentations of NCP are mostly patchy ground glass opacities in the peripheral areas under the pleura with partial consolidation which will be absorbed with formation of fibrotic stripes if improved. CT scanning provides important bases for early diagnosis and treatment of NCP.

中文翻译:

SARS-CoV-2引起的新型冠状病毒性肺炎的临床和计算机断层扫描成像特征。

目的探讨由SARS-CoV-2引起的新型冠状病毒性肺炎(NCP)的计算机断层扫描(CT)的临床和影像学特征。材料与方法对确诊为COVID-19肺炎的患者进行CT扫描并在发病后进行治疗的影像学检查进行回顾性分析。临床和影像数据进行了分析。结果共纳入50例患者,其中轻度9例,普通28例,重度10例,重度3例。轻度患者(29岁)显着(P <0.03)比普通(44.5岁)或重度(54.7)和重度(65.7岁)患者年轻,普通患者也比重度和严重患者(P <0.03)年轻(P <0.03)。重症患者。轻度患者发低烧至中度(<39.1°C),49名(98%)患者的白细胞计数正常或略有下降,14名(28%)的淋巴细胞计数降低,而26名(52%)的C反应蛋白升高。9名轻度患者的CT影像检查阴性。对于所有其他类型的NCP,病变位于右上叶30例,右中叶22例,右下叶39例,左上叶33例,左下叶36例。胸膜下的周围区域可能延伸至肺门。对称性病变见26例,非对称性病变见15例。病变的密度大多不均匀,以磨玻璃片混浊为主要表现,伴有部分巩固和纤维化。结论NCP的CT影像学表现主要是胸膜周围区域的斑片状玻璃混浊,部分固结,如果改善,将被吸收并形成纤维化条纹。CT扫描为NCP的早期诊断和治疗提供了重要的依据。
更新日期:2020-02-25
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