Presence of liver metastases correlates with worse survival and response to any treatments. This may be due to the microenvironment of liver which leads tumor to escape from Immune System. Stereotactic Body Radiation Therapy may help to sensitize Immune System and to improve the immunotherapy effect. Interest is being directed toward combining Immune-Checkpoint Inhibitors with radiotherapy to improve response to immunotherapy. However, the mechanisms by which radiation induces anti-tumor T-cells remain unclear. Preclinical studies founded radiotherapy enhances antitumor immune responses, increasing tumor antigen release, and inducing T-cell infiltration. Radiotherapy is under investigation for its ability to enhance responses to immunotherapy. Nevertheless, how to optimally deliver combination therapy regarding dose-fractionation and timing of radiotherapy is unknown. The aim of this review is to explore the role of Stereotactic Body Radiation Therapy in metastatic non-small cell lung cancer, focusing on patients with liver metastases, and the possible immunological implications combining immunotherapy and radiotherapy.

中文翻译：

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转移性非小细胞肺癌的立体定向放射疗法：结合免疫疗法和放射疗法，重点是肝转移。

肝转移的存在与较差的存活率和对任何治疗的反应有关。这可能是由于肝脏的微环境导致肿瘤从免疫系统逸出。立体定向放射疗法可能有助于提高免疫系统的敏感性，并提高免疫治疗效果。人们的兴趣是将免疫检查点抑制剂与放射疗法相结合以改善对免疫疗法的反应。然而，辐射诱导抗肿瘤T细胞的机制仍不清楚。临床前研究发现放疗可增强抗肿瘤免疫反应，增加肿瘤抗原释放并诱导T细胞浸润。放射疗法增强免疫疗法反应的能力正在研究中。不过，关于剂量分割和放疗时间的最佳组合疗法尚不清楚。这篇综述的目的是探讨立体定向放射疗法在转移性非小细胞肺癌中的作用，重点是肝转移患者，以及免疫疗法和放射疗法的潜在免疫学意义。