Due to the complexity involved in the healing process of full thickness burns, the literature looks for alternatives to optimize tissue reconstruction. The objective of this study was to explore the action of photobiomodulation therapy associated with MSCs in the healing process of third degree burns. A total of 96 male Wistar rats were used, distributed in four groups with 24 animals each: Control Group, Laser Group, Cell Therapy Group, and Laser Group and Cell Therapy. The burn was performed with aluminum plate (150 °C). We performed analysis of wound contraction, histology, immunohistochemistry, birefringence analysis, and immunoenzymatic assay to evaluate tissue quality. Our results demonstrate that the association of the techniques is able to accelerate the repair process, modulating the inflammatory process, presenting a cutaneous tissue with better quality. Thus, we conclude that the use of photobiomodulation therapy associated with cell therapy is a promising treatment in the repair of total thickness burns.

中文翻译：

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光调节与细胞疗法相关的作用在大鼠三度烧伤皮肤再生过程中的作用。

由于全厚度烧伤的愈合过程涉及复杂性，因此文献寻找可优化组织重建的替代方法。这项研究的目的是探索与MSC相关的光生物调节疗法在三度烧伤愈合过程中的作用。使用总共96只雄性Wistar大鼠，分为四组，每组24只动物：对照组，激光组，细胞治疗组，激光组和细胞治疗。用铝板（150℃）进行燃烧。我们进行了伤口收缩分析，组织学，免疫组织化学，双折射分析和免疫酶分析，以评估组织质量。我们的结果表明，这些技术的结合能够加快修复过程，调节炎症过程，呈现质量更好的皮肤组织。因此，我们得出结论，与细胞疗法相关的光生物调节疗法的使用是修复总厚度烧伤的有前途的疗法。