Abstract Electrospinning-electrospraying is a promising technique in synthesis of hybrid polymeric materials for many applications, especially for drug delivery purposes. Since one of the most worrisome adverse effects of anticancer drugs such as doxorubicin (Dox), cisplatin and Fluorouracil (5FU) is cardiotoxicity, finding a possible novel strategy to prevent or manage this lethal side effect should be considered as one of the most important issues for investigation. In this study, we fabricated a fibrous scaffold containing encapsulated Dox to prevent Dox-induced cardiomyopathy with limited clinical use and improve clinical outcomes of chemotherapy in cancer patients. Simultaneous electrospinning-electrospraying was used to produce hybrid nanofibers intended to be used for controlled releases of doxorubicin. Boron nitride nanotubes (BNNTs) clusters were synthesized and employed for encapsulation of Dox and then they were subjected to electrospraying. Electrospinning of polycaprolactone (PCL) solution was performed simultaneously to provide a nanofiber network substrate for BNNT/Dox nanocapsules. Polycaprolactone nanofibers with average diameters at the range of 240 ± 55–450 ± 50 nm were synthesized depending on various electrospinning conditions. BNNTs/Dox homogenous solution in methanol/acetone (50/50 V/V) was prepared and electrosprayed on the surface of the nanofibers. Different properties of the produced electrospun mats such as morphology, thermal characteristics and in vitro drug releases were investigated. The results revealed the excellent thermo-pH sensitivity of the prepared BNNTs/PCL functional nano-mats.

中文翻译：

---

氮化硼纳米管簇及其与聚己内酯的混合纳米纤维：热-pH 敏感药物递送功能材料

摘要 静电纺丝-电喷雾是一种用于合成杂化聚合物材料的有前景的技术，可用于多种应用，尤其是用于药物递送目的。由于多柔比星 (Dox)、顺铂和氟尿嘧啶 (5FU) 等抗癌药物最令人担忧的不良反应之一是心脏毒性，因此寻找一种可能的新策略来预防或管理这种致命的副作用应被视为最重要的问题之一进行调查。在这项研究中，我们制造了一种含有封装 Dox 的纤维支架，以预防临床使用有限的 Dox 诱发的心肌病，并改善癌症患者化疗的临床结果。同时静电纺丝-电喷雾用于生产混合纳米纤维，用于控制释放多柔比星。氮化硼纳米管 (BNNT) 簇被合成并用于封装 Dox，然后对其进行电喷雾。同时进行聚己内酯 (PCL) 溶液的静电纺丝，为 BNNT/Dox 纳米胶囊提供纳米纤维网络基材。根据不同的静电纺丝条件合成了平均直径在 240 ± 55–450 ± 50 nm 范围内的聚己内酯纳米纤维。制备了 BNNTs/Dox 在甲醇/丙酮 (50/50 V/V) 中的均质溶液并将其电喷涂在纳米纤维的表面上。研究了生产的电纺垫的不同特性，例如形态、热特性和体外药物释放。结果表明所制备的 BNNTs/PCL 功能纳米垫具有优异的热-pH 敏感性。