BACKGROUND Motivation and necessity to adopt minimally invasive therapies in the field of spinal regenerative medicine is increasing. Autologous platelet-rich plasma (PRP) therapy has recently been used as an effective technological and biological approach to tissue repair and has shown to improve multiple conditions including back pain and degenerative disc pathology. In addition, it is well established that the anatomic elements of the spinal system affected by degenerative pathology include the intervertebral disc (IVD) and vertebral subchondral bone (VSB), which play a crucial role in maintaining a healthy spinal column. Both elements are the target of a novel biological approach to the treatment of low back pain. METHODS A novel minimally invasive regenerative therapeutic approach is presented herein with a protocol based on combining vertebral intraosseous (VIO) and intradiscal (ID) infiltrations of plasma rich in growth factors (PRGF-Endoret), a type of leukocyte-free PRP, for the treatment of disc degeneration pathology. RESULTS We describe a novel technique applied in a patient treated for IVD degeneration and VSB damage, showing significant improvement on magnetic resonance imaging, including partial regression of protruded disc and significant resorption of intravertebral herniations (Schmörl's nodes), after PRGF therapy. CONCLUSIONS To the best of our knowledge, we present the first reported case description of the utilization of VIO and ID PRP infiltrations to treat protruded discs and intravertebral herniations with a successful clinical outcome.

中文翻译：

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富含生长因子（PRGF-Endoret）渗透的椎骨内血浆作为腰椎病理学中终板退行性病变的一种新治疗策略：技术描述和病例报道。

背景技术在脊柱再生医学领域中采用微创疗法的动机和必要性正在增加。自体富血小板血浆（PRP）治疗最近已被用作组织修复的有效技术和生物学方法，并已显示可改善多种状况，包括背痛和椎间盘退行性病变。此外，已经确定的是，受退行性病理影响的脊柱系统的解剖元素包括椎间盘（IVD）和椎骨软骨下骨（VSB），它们在维持健康的脊柱中起着至关重要的作用。这两种元素都是治疗腰痛的新型生物学方法的目标。方法本文提出了一种新颖的微创再生治疗方法，该方案基于将富含生长因子的血浆（PRGF-Endoret）（一种不含白细胞的PRP）的椎骨内（VIO）和椎间盘内（ID）浸润相结合的方案。椎间盘退变的病理治疗。结果我们描述了一种新技术，该技术应用于接受IVD变性和VSB损伤治疗的患者，显示出在PRGF治疗后磁共振成像的显着改善，包括椎间盘突出部分消退和椎内突出（Schmörl淋巴结）明显吸收。结论据我们所知，