Cellular organelles are membrane-bound and provide a microenvironment for specific functions. A mitochondrion is a double membranous and dynamic organelle that undergoes numerous fusion/fission events, which depends on various cellular factors. However, it is still dependent on other organelles and requires both communications as well as the movement of physical metabolites between them. Mitochondria interact with different organelles counting lipid droplets (LD), peroxisomes, vacuoles, endoplasmic reticulum (ER) and plasma membrane (PM), etc. Apart from them, mitochondria maintain multiple interactions with ER including ERMES (Endoplasmic Reticulum and Mitochondria Encounter Structures). ERMES is actually a multi-protein complex, and imperative in the maintenance of mitochondrial morphology and its functions. Its disruption also compromises phospholipid exchange, drug resistance and pathogenicity. This assembly is reportedly unique to fungal systems and proposed as a target for development of new antifungal. In the light of separate reports across diverse fungal systems, we have summarised the information about its distribution and effect on mitochondrial fitness.

中文翻译：

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ERMES（内质网和线粒体接触结构）介导的真菌功能

细胞器是膜结合的，为特定功能提供微环境。线粒体是一种双膜和动态细胞器，它经历了许多融合/裂变事件，这取决于各种细胞因素。然而，它仍然依赖于其他细胞器，并且需要它们之间的通信以及物理代谢物的运动。线粒体与计数脂滴 (LD)、过氧化物酶体、液泡、内质网 (ER) 和质膜 (PM) 等的不同细胞器相互作用。除此之外，线粒体与 ER 保持多种相互作用，包括 ERMES（内质网和线粒体相遇结构） . ERMES 实际上是一种多蛋白复合物，对于维持线粒体形态及其功能是必不可少的。它的破坏还会损害磷脂交换、耐药性和致病性。据报道，该组件是真菌系统独有的，并被提议作为开发新抗真菌剂的目标。根据不同真菌系统的单独报告，我们总结了有关其分布和对线粒体健康影响的信息。