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3D Printed Sugar-Sensing Hydrogels.
Macromolecular Rapid Communications ( IF 4.6 ) Pub Date : 2020-02-24 , DOI: 10.1002/marc.201900610
Danielle Bruen 1, 2 , Colm Delaney 3 , Johnson Chung 2 , Kalani Ruberu 2 , Gordon G Wallace 2 , Dermot Diamond 1 , Larisa Florea 4
Affiliation  

The ability of boronic acids (BAs) to reversibly bind diols, such as sugars, has been widely studied in recent years. In solution, through the incorporation of additional fluorophores, the BA-sugar interaction can be monitored by changes in fluorescence. Ultimately, a practical realization of this technology requires a transition from solution-based methodologies. Herein, the first example of 3D-printed sugar-sensing hydrogels, achieved through the incorporation of a BA-fluorophore pair in a gelatin methacrylamide-based matrix is presented. Through optimization of monomeric cocktails, it is possible to use extrusion printing to generate structured porous hydrogels which show a measurable and reproducible linear fluorescence response to glucose and fructose up to 100 mm.

中文翻译:

3D打印的糖感水凝胶。

近年来,硼酸(BAs)可逆地结合二醇(如糖)的能力已得到广泛研究。在溶液中,通过加入其他荧光团,可以通过荧光变化来监测BA-糖的相互作用。最终,该技术的实际实现需要从基于解决方案的方法论过渡。本文介绍了通过在明胶甲基丙烯酰胺基基质中掺入BA-荧光团对而实现的3D打印糖感水凝胶的第一个例子。通过优化单体混合物,可以使用挤出印刷生成结构化的多孔水凝胶,该凝胶对高达100 mm的葡萄糖和果糖显示出可测量和可再现的线性荧光响应。
更新日期:2020-02-24
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