Solute carrier proteins (SLCs), the most understudied and second largest group of membrane proteins, maintain cellular metabolic homeostasis via the export and import of various solute, ions, metabolites, and even drugs. Given the importance of SLCs in maintaining normal cellular function, dysregulation of these proteins leads to the dramatic progression of cancers in neoplastic cells. The importance of these transporters as drug targets is gradually being realized by the scientific community. In this review, we describe the role of SLCs in hallmarks of cancer, focusing mainly on the connection between oncogenes (Myc) and SLCs in breast cancer. We also discussed the role of glucose and amino acid transporters in cancer cells and how they can be manipulated to develop anticancer therapies.

溶质载体蛋白 (SLC) 是研究最深入和第二大的膜蛋白组，通过各种溶质、离子、代谢物甚至药物的输出和输入来维持细胞代谢稳态。鉴于 SLC 在维持正常细胞功能方面的重要性，这些蛋白质的失调会导致肿瘤细胞中癌症的急剧发展。科学界逐渐意识到这些转运蛋白作为药物靶点的重要性。在这篇综述中，我们描述了 SLC 在癌症标志中的作用，主要关注癌基因 (Myc) 和乳腺癌中 SLC 之间的联系。我们还讨论了葡萄糖和氨基酸转运蛋白在癌细胞中的作用以及如何操纵它们来开发抗癌疗法。