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Lymphatic endothelial cells of the lymph node.
Nature Reviews Immunology ( IF 100.3 ) Pub Date : 2020-02-24 , DOI: 10.1038/s41577-020-0281-x
Sirpa Jalkanen 1, 2 , Marko Salmi 1, 2
Affiliation  

The influx and efflux of cells and antigens to and from the draining lymph nodes largely take place through the subcapsular, cortical and medullary sinus systems. Recent analyses in mice and humans have revealed unexpected diversity in the lymphatic endothelial cells, which form the distinct regions of the sinuses. As a semipermeable barrier, the lymphatic endothelial cells regulate the sorting of lymph-borne antigens to the lymph node parenchyma and can themselves serve as antigen-presenting cells. The leukocytes entering the lymph node via the sinus system and the lymphocytes egressing from the parenchyma migrate through the lymphatic endothelial cell layer. The sinus lymphatic endothelial cells also orchestrate the organogenesis of lymph nodes, and they undergo bidirectional signalling with other sinus-resident cells, such as subcapsular sinus macrophages, to generate a unique lymphatic niche. In this Review, we consider the structural and functional basis of how the lymph node sinus system coordinates immune responses under physiological conditions, and in inflammation and cancer.



中文翻译:

淋巴结的淋巴管内皮细胞。

细胞和抗原流入和流出引流淋巴结的流入和流出主要通过囊下,皮质和髓窦系统进行。最近在小鼠和人类中进行的分析表明,淋巴管内皮细胞具有意想不到的多样性,形成了鼻窦的不同区域。作为半透性屏障,淋巴管内皮细胞调节淋巴结实质中淋巴携带的抗原的分类,它们本身可以充当抗原呈递细胞。通过鼻窦系统进入淋巴结的白细胞和从实质流出的淋巴细胞通过淋巴管内皮细胞层迁移。窦性淋巴管内皮细胞还可以协调淋巴结的器官发生,并与其他窦性驻留细胞进行双向信号传导,如荚膜下窦巨噬细胞,产生独特的淋巴位。在这篇综述中,我们考虑了淋巴结窦系统如何在生理条件下以及炎症和癌症中协调免疫反应的结构和功能基础。

更新日期:2020-02-24
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