Agricultural pesticides are extensively used for weed- and pest control, resulting in residues of these compounds in food. The general population is mainly exposed through dietary intake. Exposure to certain pesticides has been associated with adverse human health outcomes. Our aim was to assess urinary concentrations and temporal trends in the biomarkers of commonly used pesticides. Samples were collected from adolescents (n = 1060) in Scania, Sweden, from 2000 to 2017. Concentrations of 14 pesticide biomarkers were analyzed in urine using LC–MS/MS. Temporal trends in biomarker concentrations (ln-transformed) were evaluated using linear regression. Biomarkers of pyrethroids (3-PBA and DCCA), chlorpyrifos (TCPy), chlormequat (CCC), thiabendazole (OH-TBZ), and mancozeb (ETU) were detected in >90% of the population all sampling years. The biomarkers CCC and TCPy had the highest median concentrations (>0.8 µg/L), whereas the biomarkers of cyfluthrin (4F-3-PBA) and two pyrethroids (CFCA) had the lowest median concentrations (<0.02 µg/L). Increasing temporal trends were found for the biomarkers 3-PBA (3.7%/year), TCPy (1.7%/year) and biomarkers of pyrimethanil (11.9%/year) and tebuconazole (12.2%/year). Decreasing trends were found for CCC (–5.5%/year), OH-TBZ (−5.5%/year), and ETU (−3.9%/year). Our results suggest that Swedish adolescents are commonly exposed to pesticides in low concentrations (median concentrations <3.88 µg/L).

农业杀虫剂被广泛用于杂草和害虫防治，从而在食品中残留这些化合物。普通人群主要通过饮食摄入暴露。暴露于某些农药与人类健康的不良后果有关。我们的目的是评估常用农药生物标志物中的尿液浓度和时间趋势。从青少年（n = 2000年至2017年在瑞典的斯堪尼亚（1060）。使用LC-MS / MS分析了尿液中14种农药生物标志物的浓度。使用线性回归评估生物标志物浓度（经转化）的时间趋势。在所有采样年中，> 90％的人口中检出了拟除虫菊酯（3-PBA和DCCA），毒死rif（TCPy），毒死qua（CCC），噻菌灵（OH-TBZ）和曼考布（ETU）的生物标志物。生物标志物CCC和TCPy的中位浓度最高（> 0.8 µg / L），而氟氰菊酯（4F-3-PBA）和两种拟除虫菊酯（CFCA）的生物标志物最低中位浓度（<0.02 µg / L）。发现3-PBA（3.7％/年），TCPy（1.7％/年）和嘧啶酮（11.9％/年）和戊唑醇（12.2％/年）的生物标志物的时间趋势在增加。发现CCC（-5.5％/年），OH-TBZ（-5）呈下降趋势。5％/年）和ETU（−3.9％/年）。我们的结果表明，瑞典青少年通常以低浓度（中位数浓度<3.88 µg / L）接触农药。