Phosphoinositides are signaling lipids that recruit effector proteins to membranes. Shin et al. show that a glucose-starvation-induced drop in cytosolic pH alters the protonation state of the phosphoinositide PI4P, resulting in dissociation of its effector Osh1 from the trans-Golgi network membrane and metabolic regulation of lipid and protein sorting.

中文翻译：

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磷酸肌醇信号传导的酸甜味：PI4P的质子化调节其功能以响应细胞质pH的变化。

磷酸肌醇是信号脂质，其将效应蛋白募集到膜上。Shin等。结果表明，葡萄糖饥饿诱导的胞质pH下降会改变磷酸肌醇PI4P的质子化状态，从而导致其效应物Osh1从反高尔基体网络膜上解离，并进行脂质和蛋白质分选的代谢调控。