An eco-friendly, efficient and green one-pot multicomponent preparation of pyridopyrimidine is reported. A mixture of urea/CuCl₂ was prepared and used as efficient catalyst to synthesize a various derivative of pyridopyrimidine with excellent yields in short times of reaction using microwave irradiation. All product were obtained with excellent yields (94-98%) in short time of reaction (few minutes). This green deep eutectic solvents was recycled and reutilized for many cycles without showing any significant loss of performance. The synthesized compounds were assessed for their activity against some bacterial strains. Therefore, just 6 compounds were showed active against the targeted bacterial strains.

报道了一种嘧啶嘧啶的生态友好，有效和绿色的一锅多组分制剂。制备尿素/ CuCl _2的混合物，并将其用作高效催化剂，以微波辐射在短时间内反应中以优异的产率合成吡啶并嘧啶的各种衍生物。在短的反应时间（几分钟）内以优异的产率（94-98％）获得所有产物。将这种绿色的深共熔溶剂循环使用许多次，而没有表现出任何明显的性能损失。评估合成的化合物对某些细菌菌株的活性。因此，仅显示出6种化合物对目标细菌菌株具有活性。