Two new polyketides (1–2), four new norterpenoids (3–6), together with five known compounds (7–11) were isolated from the marine sponge Diacarnus megaspinorhabdosa. The new structures were determined by extensive spectroscopic analyses, ECD spectra comparison, and Mosher's method. The cytotoxicities towards six cancer cell lines together with the antimicrobial activity against methicillin-resistant Staphylococcus aureus, Canadida albicans, and Escherichia coli were valuated. Compound 10 showed cytotoxicities towards cancer cell lines SW480, NCI–H460, PC−9, and HepG2, with IC₅₀ 3.7, 7.8, 6.2 and 8.0 μM respectively.

两个新的聚酮化合物（1 - 2），四个新norterpenoids（3 - 6）中，用5个已知的化合物（一起7 - 11）从海绵中分离Diacarnus megaspinorhabdosa。通过广泛的光谱分析，ECD光谱比较和Mosher方法确定了新结构。评估了对六种癌细胞系的细胞毒性以及对耐甲氧西林金黄色葡萄球菌，白色念珠菌和大肠杆菌的抗菌活性。化合物10表现出对癌细胞系SW480，NCI-H460，PC-9和HepG2的细胞毒性，IC ₅₀分别为3.7、7.8、6.2和8.0μM。